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Granzymes

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Definition: A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.     
Pharmacological Action Cytotoxins 		Other names Natural Killer Cell Granule Tryptase 2; NK Tryptase 2; Granzyme Like Protein III; Granzyme 3; Cytotoxic T Lymphocyte Proteinase 1; Cytotoxic T Lymphocyte Associated 1 Protein; Natural Killer Cell Granule Tryptase-2; NK-Tryptase-2; Hanukah Factor; Granzyme-Like Protein III; Granzyme-3; Granzyme M; Granzyme K; Granzyme C; Granzyme B; Granzyme A; Fragmentin 2; Cytotoxic T-Lymphocyte Proteinase 1; Cytotoxic T-Lymphocyte Associated 1 Protein; Cytotoxic Serine Protease B
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Gzmm protein, rat  EC 3.4.21.-   *Granzymes.
Gzmm protein, mouse  EC 3.4.21.-   *Granzymes.
GZMM protein, human  EC 3.4.21.-   *Granzymes.
Gzmc protein, rat  EC 3.4.21.-   *Granzymes.
Gzmc protein, mouse  EC 3.4.21.-   *Granzymes.
Gzmb protein, rat  EC 3.4.21.-   *Granzymes.
Gzmb protein, mouse  EC 3.4.21.-   *Granzymes.
GZMB protein, human  EC 3.4.21.-   *Granzymes.
GZMA protein, human  EC 3.4.21.78   *Granzymes.
Gzmn protein, mouse  EC 3.4.21.-   *Granzymes. Biol Reprod 2004 Dec;71(6):1785-95
GZMK protein, human  EC 3.4.21.-   *Granzymes. Immunogenetics 1994;40(3):235-7
GZMH protein, human  EC 3.4.21.-   *Granzymes. Int Immunol 1991;3(1):57
Gzmg protein, mouse  EC 3.4.21.-   *Granzymes. J Immunol 1990;145(8):3111
Gzmf protein, mouse  EC 3.4.21.-   *Granzymes. Proc Natl Acad Sci USA 1988;85(13):4814
Gzme protein, mouse  EC 3.4.21.-   *Granzymes. Proc Natl Acad Sci USA 1988;85(13):4814
Gzmd protein, mouse  EC 3.4.21.-   *Granzymes. Proc Natl Acad Sci USA 1988;86(13):4814

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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