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I-kappa B Kinase

More information in Books or onNLM PubMed
Definition: A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.     
See Also I-kappa B Proteins 		Other names NK kappa B Activating Kinase NAK; NF kappaB Essential Modifier; Kinase, IkappaB; Kinase, I-kappa B; Kinase epsilon, IkappaB; Kinase beta, IkappaB; Kinase alpha, IkappaB; I Kappa B alpha Associated Protein Kinase; Essential Modifier, NF-kappaB; Conserved Helix Loop Helix Ubiquitous Kinase; B Kinase, I-kappa; NK-kappa B-Activating Kinase NAK; NF-kappaB Essential Modifier; IkappaBalpha Kinase; IkappaB Kinase gamma; IkappaB Kinase epsilon; IkappaB Kinase beta; IkappaB Kinase alpha; IkappaB Kinase; IKKepsilon
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
IKK2 protein, mouse  EC 2.7.1.37   *I-kappa B Kinase. PLoS One. 2011;6(10) (dup#6):e25942
N-(4-nitrobenzylidene)-2-naphthohydrazide  0   *Hydrazones I-kappa B Kinase/antagonists & inhibitors. Eur J Med Chem 2011 Apr;46(4):1245-53
2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimiazo(4,5-d)pyrrolo(2,3-b)pyridin-7-yl)pyridin-2-yl)methyl)acetamide  0   *Acetamides *Heterocyclic Compounds, 3-Ring I-kappa B Kinase/antagonists & inhibitors. J Pharmacol Exp Ther 2009 Nov;331(2):349-60
2-(4-((4-amino-2-methylphenyl)diazenyl)phenylsulfonyl)ethanesulfonoperoxoic acid  0   *Azo Compounds *Sulfonic Acids I-kappa B Kinase/antagonists & inhibitors. Mol Cancer Ther 2009 Mar;8(3):571-81
N-(3-(dimethylamino)propyl)-4-((4-(3-fluoro-4-methoxyphenyl)pyrimidin-2-yl)amino)benzenesulfonamide  0   *Pyrimidines *Sulfonamides I-kappa B Kinase/antagonists & inhibitors. Cancer Res 2008 Nov 15;68(22):9519-24
17-acetoxyjolkinolide B  0   *Diterpenes I-kappa B Kinase/antagonists & inhibitors. Mol Cancer Ther 2008 Ther;2008 Jun;7(6):1523-32
NEMO protein, rat  0   *Intracellular Signaling Peptides and Proteins I-kappa B Kinase. FEBS J 2007 May;274(10):2540-51
IKK2 protein, rat  EC 2.7.1.37   *I-kappa B Kinase. Transplantation. 2007 Feb 27;83(4):474-84
Ik2 protein, Drosophila  EC 2.7.1.37   *Drosophila Proteins *I-kappa B Kinase. Development 2006 Apr;133(8):1467-75
Ikbke protein, mouse  EC 2.7.1.-   *I-kappa B Kinase.
IKBKE protein, human  EC 2.7.1.-   *I-kappa B Kinase.
Chuk protein, mouse  EC 2.7.1.-   *I-kappa B Kinase.
ird5 protein, Drosophila  EC 2.7.1.37   *Drosophila Proteins *I-kappa B Kinase.
Ikbkb protein, mouse  EC 2.7.1.37   *I-kappa B Kinase.
IKBKB protein, human  EC 2.7.11.10   *I-kappa B Kinase.
CHUK protein, human  EC 2.7.11.10   *I-kappa B Kinase.
IKBKG protein, human  0   *I-kappa B Kinase.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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