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Receptor, Serotonin, 5-HT2C

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Definition: A serotonin receptor subtype found primarily in the CENTRAL NERVOUS SYSTEM and the CHOROID PLEXUS. This receptor subtype is believed to mediate the anorectic action of SEROTONIN, while selective antagonists of the 5-HT2C receptor appear to induce ANXIETY. Several isoforms of this receptor subtype exist, due to adenine deaminase editing of the receptor mRNA.      Other names Receptor, Serotonin 2C; Receptor, 5-HT2C; Receptor, 5 Hydroxytryptamine Type 2C; 5 Hydroxytryptamine Type 2C Receptors; 5 Hydroxytryptamine Type 2C Receptor; 5 HT2C Receptor; 2C Receptor, Serotonin; Receptor, 5-Hydroxytryptamine Type 2C; 5-Hydroxytryptamine Type 2C Receptors; 5-Hydroxytryptamine Type 2C Receptor; 5-HT2C Receptor; 5-HT(2C) Receptor; Serotonin 2C Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PF 3246799  0   *Azepines *Pyrimidines Serotonin Receptor Agonists Receptor, Serotonin, 5-HT2C. Bioorg Med Chem Lett 2011 May 1;21(9):2715-20
vabicaserin  0   *Heterocyclic Compounds with 4 or More Rings Receptor, Serotonin, 5-HT2C. Drug Metab Dispos 2010 Apr;38(4):581-90
(2-(3-methylphenyl)cyclopropyl)methylamine  0   *Cyclopropanes *Methylamines Receptor, Serotonin, 5-HT2C/agonists. J Med Chem 2009 Apr 9;52(7):1885-902
9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino(2,1-a)isoindol-6(2H)-one  0   *Pyrazines *Isoindoles Receptor, Serotonin, 5-HT2C/agonists. J Med Chem 2007 Mar 22;50(6):1365-79
1-(3-(2-((2-ethoxy-3-pyridinyl)oxy)ethoxy)-2-pyrazinyl)-2-methylpiperazine  0   *Piperazines *Pyrazines Receptor, Serotonin, 5-HT2C/agonists. J Pharm Biomed Anal 2006 Mar 18;40(5):1121-30
1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole  0   *Azepines *Indoles Receptor, Serotonin, 5-HT2C/agonists. J Pharmacol Exp Ther 2005 May;313(2):862-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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