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Receptor, Serotonin, 5-HT1B

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Definition: A serotonin receptor subtype found at high levels in the BASAL GANGLIA and the frontal cortex. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1D RECEPTOR. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigraine effect.      Other names Receptors, Serotonin 1Dbeta; Receptors, 5-Hydroxytryptamine 1B; Receptor, Serotonin 1Dbeta; Receptor, Serotonin 1B; Receptor, 5-HT1Dbeta; Receptor, 5-HT1B; Receptor, 5 Hydroxytryptamine 1B; 5 Hydroxytryptamine 1B Receptors; 5 Hydroxytryptamine 1B Receptor; 5 HT1Dbeta Receptor; 5 HT1B Receptor; 1Dbeta Receptors, Serotonin; 1Dbeta Receptor, Serotonin; 1B Receptors, 5-Hydroxytryptamine; 1B Receptor, Serotonin; 1B Receptor, 5-Hydroxytryptamine; Serotonin 1Dbeta Receptors; Serotonin 1Dbeta Receptor; Serotonin 1D Beta Receptor; Receptor, Serotonin Type 1Dbeta
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-(3,4-dichlorophenyl)-2-(2-(4-methylpiperazin-1-yl)benzylidene)thiomorpholin-3-one  0   *Morpholines *Piperazines Receptor, Serotonin, 5-HT1B. Drug Metab Dispos 2010 Nov;38(11):1984-99
6-(2-(4-(2-methyl-5-quinolinyl)-1-piperazinyl)ethyl)-4H-imidazo(5,1-c)(1,4)benzoxazine-3-carboxamide  0   *Benzoxazines Receptor, Serotonin, 5-HT1A Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT1D. J Med Chem 2010 Aug 12;53(15):5827-43
1-(4-(2-methoxyisopropyl)phenyl)-3-(2-(4-methylpiperazin-1-yl)benzyl)pyrrolidin-2-one  0   *Piperazines *Pyrrolidinones Receptor, Serotonin, 5-HT1B/antagonists & inhibitors. J Cereb Blood Flow Metab 2010 Jan;30(1):196-210
HTR1B protein, human  0   *Receptor, Serotonin, 5-HT1B.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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