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Ubiquitin Thiolesterase

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Definition: A thioester hydrolase which acts on esters formed between thiols such as DITHIOTHREITOL or GLUTATHIONE and the C-terminal glycine residue of UBIQUITIN.      Other names Ubiquitin Carboxy Terminal Hydrolase; Ubiquitin Carboxy Terminal Esterase; Ubiquitin C Terminal Hydrolase; Ubiquitin C Terminal Esterase; Thiolesterase, Ubiquitin; Hydrolase, Ubiquitin Carboxy-Terminal; Hydrolase, Ubiquitin C-Terminal; Esterase, Ubiquitin Carboxy-Terminal; Esterase, Ubiquitin C-Terminal; Carboxy-Terminal Hydrolase, Ubiquitin; Carboxy-Terminal Esterase, Ubiquitin; C-Terminal Hydrolase, Ubiquitin; C-Terminal Esterase, Ubiquitin; Ubiquitin Carboxy-Terminal Hydrolase; Ubiquitin Carboxy-Terminal Esterase; Ubiquitin C-Terminal Hydrolase; Ubiquitin C-Terminal Esterase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
USP49 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase. Int J Legal Med. 2012 Jan;126(1):55-62
ubiquitin carboxyl-terminal hydrolase 47, human  EC 3.1.2.15   *Ubiquitin Thiolesterase. Mol Cell. 2011 Mar 4;41(5):609-15
USP9X protein, rat  EC 3.4.19.12   *Ubiquitin Thiolesterase. PLoS One 2010;5(3):e9725
Usp8 protein, mouse  0   *Endopeptidases *Ubiquitin Thiolesterase *Endosomal Sorting Complexes Required for Transport.
USP8 protein, human  0   *Endopeptidases *Ubiquitin Thiolesterase *Endosomal Sorting Complexes Required for Transport. Trends Biochem Sci. 2007 Dec;32(12):561-73
UCHL3 protein, mouse  EC 3.1.2.15   *Ubiquitin Thiolesterase. Biochem Biophys Res Commun 2001 May 11;283(3):627-33
Usp16 protein, Xenopus  EC 3.1.2.15   *Xenopus Proteins *Ubiquitin Thiolesterase. Nature 2007 Oct 25;449(7165) (dup#1):1068-72
UCH-L1 protein, rat  EC 3.1.2.15   *Ubiquitin Thiolesterase. Brain Res 2006 Nov 22;1121(1):216-20
USP24 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase Parkinson Disease. Hum Mutat 2006 Oct;27(10):1017-23
USP40 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase Parkinson Disease. Hum Mutat 2006 Oct;27(10):1017-23
USP14 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase. Oncol Rep. 2006 Mar;15(3):539-43
Ubiquitin carboxyl-Terminal Hydrolase L-1, human  EC 3.1.2.15   *Ubiquitin Thiolesterase. Biochem Biophys Res Commun 2006 Jan 13;339(2):717-25
USP9X protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase Ubiquitins. Science. 2005 Dec 2;310(5753):1499-504
USP36 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase. Biochem Biophys Res Commun 2005 May 13;330(3):797-804
PGP9.5 protein, mouse  EC 3.1.2.-   *Ubiquitin Thiolesterase. J Neuroimmunol 2005 Jan;158(1-2):128-37
PGP9.5 protein, rat  EC 3.1.2.-   *Ubiquitin Thiolesterase Tumor Markers, Biological. Nagoya J Med Sci 2004 May;67(1-2):25-34
UBP16 protein, S cerevisiae  EC 3.1.2.15   *Membrane Proteins *Mitochondrial Proteins *Ubiquitin Thiolesterase. FEBS Lett 2003 Aug 14;549(1-3):135-40
STAMBP protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase *Endosomal Sorting Complexes Required for Transport src Homology Domains. Trends Biochem Sci. 2007 Dec;32(12):561-73
USP12 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase.
USP4 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase.
Ubiquitin carboxyl-Terminal Hydrolase L-1, mouse  EC 3.1.2.15   *Ubiquitin Thiolesterase. J Neurochem. 2004 Mar;88(6):1540-6
UCHL1 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase Tumor Markers, Biological. Eur J Cancer. 2004 Mar;40(4); 614-8
Uch-L1 protein, zebrafish  EC 3.1.2.15   *Zebrafish Proteins *Ubiquitin Thiolesterase. Biochem Biophys Res Commun 2003 Dec 19;312(3):601-7
USP9Y protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase. Mamm Genome. 2003 Jul;14(7):437-47
STAMBPL1 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase. Biochem Biophys Res Commun. 2003 Jul 4;306(3):637-43
USP6 protein, human  EC 3.1.2.15   *Proto-Oncogene Proteins *Ubiquitin Thiolesterase. Oncogene 1992 Apr;7(4):733-41; Proc Natl Acad Sci U S A 2003 Mar 4;100(5):2507-11
Usp14 protein, mouse  EC 3.1.2.15   *Ubiquitin Thiolesterase. Nat Genet 2002 Nov;32(3):420-5
Usp2 protein, rat  EC 3.4.19.12   *Muscle Proteins *Ubiquitin Thiolesterase. Proc Natl Acad Sci U S A 2002 Jul 23;99(15):9733-8
USP7 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase. EMBO J 1997 Apr 1;16(7):1519-30; Mol Cell Neurosci 2002 Jun;20(2):298-306
USP20 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase. Biochem Biophys Res Commun 2002 Jun 14;294(3):700-9
USP33 protein, human  EC 3.4.99.-   *Ubiquitin Thiolesterase. J Biol Chem 2002 Feb 15;277(7):4656-62
USP28 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase. Genome Biol 2001;2(10):0043
Stambp protein, mouse  EC 3.4.99.-   *Endopeptidases *Ubiquitin Thiolesterase *Endosomal Sorting Complexes Required for Transport src Homology Domains. Mol Cell Biol 2001 Dec;21(24):8626-37
USP10 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase Ubiquitins. Oncogene 2001 Jun 28;20(29):3869-79
USP21 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase. J Biol Chem 2000 May 12;275(19):14212-6
USP25 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase. Genomics 1999 Dec 15;62(3):395-405
UBP10 protein, S cerevisiae  EC 3.1.2.15   *Nuclear Proteins *Saccharomyces cerevisiae Proteins *Ubiquitin Thiolesterase. Mol Cell Biol 1999 Oct;19(10):6598-607
BAP1 protein, human  EC 3.1.2.15   *Tumor Suppressor Proteins *Ubiquitin Thiolesterase. Cancer Lett 1999 Sep;143 Suppl 1:S13-7
USP16 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase Ubiquitins. Proc Natl Acad Sci USA 1999 Mar 16;96(6):2828-33
DOA4 protein, S cerevisiae  EC 3.1.2.15   *Endopeptidases *Saccharomyces cerevisiae Proteins *Ubiquitin Thiolesterase *Endosomal Sorting Complexes Required for Transport. Nature 1993 Nov 25;366(6453):313-19; Trends Biochem Sci. 2007 Dec;32(12):561-73
ubiquitin-Nalpha-protein hydrolase  EC 3.4.99.-   *Endopeptidases Ubiquitin Thiolesterase. Proc Natl Acad Sci USA 1989;86(8):2540

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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