Definition: A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.
see SCR for specific hnRNP entries
Other names dC Stretch Binding Protein; Ribonucleoprotein K, Heterogeneous-Nuclear; Heterogeneous Nuclear Ribonucleoprotein K; hnRNP K Protein; hnRNP K; dC-Stretch-Binding Protein; Heterogeneous Nuclear Ribonucleoprotein Particle K
