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Aristolochic Acids

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Definition: Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES).     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-methoxyl aristolactam I N-beta-glucoside  0   *Glucosides *Aristolochic Acids. Asian Nat Prod Res. 2012;14(3):276-80
3,5-dihydroxy-2,4-dimethoxyaristolactam  0   *Aristolochic Acids Alkaloids. Fitoterapia. 2011 Oct;82(7):964-8
aristolochic acid F  0   *Aristolochic Acids. Chem Pharm Bull (Tokyo). 2010;58(8):1093-5
aristolochic acid G  0   *Aristolochic Acids. Chem Pharm Bull (Tokyo). 2010;58(8):1093-5
pressalanine B  0   *Aristolochic Acids. Nat Prod Res. 2010 Mar;24(4):326-30
pressalanine A  0   *Aristolochic Acids. Nat Prod Res. 2010 Mar;24(4):326-30
aristololactam A II  0   *Aristolochic Acids. Yao Xue Xue Bao 2007 Apr;42(4):405-7
cepharanone  0   *Aristolochic Acids. Yao Xue Xue Bao 2007 Apr;42(4):405-7
aristololactam-I  0   *Aristolochic Acids. Zhongguo Zhong Yao Za Zhi 2008 Apr;33(7):793-7
7-methoxyaristololactam IV  0   *Aristolochic Acids. Nephron Exp Nephrol 2006;103(3):e95-e102
9-hydroxy aristolochic acid I  0   *Aristolochic Acids. Pharmazie. 2005 Oct;60(10):785-8
aristololactam IVa  0   *Aristolochic Acids. Pharmazie. 2005 Oct;60(10):785-8
7-(deoxyguanosin-N(2)--yl)aristolactam II  0   *Aristolochic Acids Deoxyguanosine/*analogs & derivatives DNA Adducts. Carcinogenesis 2000 Feb;21(2):235-42
7-(deoxyadenosin-N(6)--yl)aristolactam II  0   *Deoxyadenosines *Aristolochic Acids DNA Adducts. Carcinogenesis 2000 Feb;21(2):235-42
aristolactam I  13395-02-3   *Aristolochic Acids. Exp Toxicol Pathol 1999 Jul;51(4-5):421-7
aristoloside  84014-70-0   *Aristolochic Acids Aristolochia. Anticancer Res 1997 Jan-Feb;17(1A):237-40
7-methoxyaristolochic acid A  0   *Aristolochic Acids. Chung Kuo Chung Yao Tsa Chih 1994 Nov;19(11):677-8
aristolochic acid C  4849-90-5   *Aristolochic Acids Aristolochia. Chung Kuo Chung Yao Tsa Chih 1994 Nov;19(11):677-8
N-((6'-p-coumaroyl)glucopyranosyl)aristolactam  145613-84-9   *Glucosides *Aristolochic Acids. J Nat Prod 1992 Sep;55(9):1165-9
7-(deoxyadenosin-N(6)-yl)aristolactam I  127191-86-0   *Deoxyadenosines *Aristolochic Acids. Carcinogenesis 1992 Oct;13(10):1835-9
7-(deoxyguanosin-N(2)-yl)aristolactam I  127191-85-9   *Aristolochic Acids Deoxyguanosine/*analogs & derivatives. Carcinogenesis 1992 Oct;13(10):1835-9
aristololactam BII  53948-09-7   *Aristolochic Acids Plants. J Nat Prod 1990;53(2):309
aristololactam-glucoside  17413-41-1   *Glucosides *Aristolochic Acids. Biochem Pharmacol 1989;38(21):3683
9-ethoxyaristololactam  122739-09-7   *Aristolochic Acids Aristolochia. Yao Hsueh Hsueh Pao 1989;24(4):307
9-ethoxyaristolactone  122739-10-0   *Aristolochic Acids Aristolochia. Yao Hsueh Hsueh Pao 1989;24(4):305
aristolochic acid E  107259-48-3 Phenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid, 8-hydroxy-9-methoxy-6-nitro  *Aristolochic Acids Aristolochia. Yao Hsueh Hsueh Pao 1986;21(9):702
aristolochic acid II  475-80-9   *Aristolochic Acids Aristolochia. Cancer Lett 1984;32(1):97
9-nitrophenanthrene  954-46-1   *Phenanthrenes Aristolochic Acids. Cancer Lett 1984;32(1):97
methyl aristolate  35142-06-4 8-methoxyphenanthro(3,4-d)-1,3-dioxole-5- carboxylic acid, methyl ester  *Aristolochic Acids Aristolochia. Indian J Exp Biol 17(4):437;1979
aristolic acid  35142-05-3 Phenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid, 8-methoxy  *Aristolochic Acids. Experientia 34(10):1377;1978
aristolochic acid I  313-67-7   *Aristolochic Acids.
Pharma Action Antiviral Agents ; Carcinogens ; Mutagens 		Arzneim Forsch 27(12):2297;1977; Experientia 34(9):1192;1978; Il Farm 27(4):257;1972; J Pharm Sci 64(2):345;1975; Osterr Z Onkol 2(6):151;1976

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