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Phosphofructokinase-2

More information in Books or onNLM PubMed
Definition: An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.     
See Also Phosphofructokinase-1 		Other names Phosphofructokinase 2; fructose-2,6-diphosphatase; Fructose-6-phosphate,2-kinase-fructose-2,6-bisphos; Fructose-6-phosphate,2-kinase; Fructose-6-P,2-kinase; Fructose-2,6-bisphosphate 2-phosphatase; Fructose 2,6-bisphosphatase; Fru-kinase-Fru-bisphosphatase; F Kinase-F-bisphosphatase; ATP-D-Fructose-6-phosphate 2-phosphotransferase; Fru-6-P,2-kinase; 6-Phosphofructo 2-kinase-fructose 2,6-bisphosphata; 6-PF-2-K-Fru-2,6-P(2)ase; 6PF2K; Fructose-2,6-bisphosphatase; 6-Phosphofructo-2-kinase-fructose-2,6-bisphosphata; 6-Phosphofructo-2-kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PFKFB2 protein, human  EC 2.7.1.105   *Phosphofructokinase-2. Biochem J. 2010 Dec 15;433(1):225-33
Pfkfb4 protein, rat  0   *Phosphofructokinase-2. Biochem Biophys Res Commun. 2009 Sep 18;387(2):330-5
Pfkfb3 protein, rat  EC 2.7.1.105   *Phosphofructokinase-2. J Neurochem 1997 Jul;69(1):1-9
PFKFB4 protein, human  0   *Phosphofructokinase-2. Biochimie 2005 Nov;87(11):1005-10
PFKFB3 protein, human  EC 2.7.1.105   *Phosphofructokinase-2. Mol Endocrinol 1997 Apr;11(4):490-502

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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