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Mitogen-Activated Protein Kinases

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Definition: A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).     
See Also MAP Kinase Signaling System
Examples Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases 		Other names Protein Kinases, Mitogen-Activated; Mitogen Activated Protein Kinases; Kinases, Mitogen-Activated Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MPK8 protein, Arabidopsis  EC 2.7.11.24   *Mitogen-Activated Protein Kinases *Arabidopsis Proteins. Mol Cell 2011 Mar 18;41(6):649-60
MPK11 protein, Arabidopsis  EC 2.7.11.24   *Mitogen-Activated Protein Kinases *Arabidopsis Proteins. Plant Cell 2010 Nov;22(11):3778-90
KSS1 protein, S cerevisiae  EC 2.7.11.24   *Mitogen-Activated Protein Kinases *Saccharomyces cerevisiae Proteins.
MKK9 protein, Arabidopsis  EC 2.7.1.-   *Mitogen-Activated Protein Kinases *Arabidopsis Proteins. Nature. 2008 Feb 14;451(7180):789-95
Spc1 protein, S pombe  EC 2.7.1.37   *Mitogen-Activated Protein Kinases *Schizosaccharomyces pombe Proteins. Nature 1995 Dec 14;378(6558):739-43
TVK1 protein, Trichoderma virens  EC 2.7.1.37   *Mitogen-Activated Protein Kinases Fungal Proteins. Microbiology 2007 Jul;153(Pt 7):2137-47
DYF-5 protein, C elegans  EC 2.7.1.37   *Mitogen-Activated Protein Kinases *Caenorhabditis elegans Proteins. Proc Natl Acad Sci U S A 2007 Apr 24;104(17):7157-62
Pmk1 protein, S pombe  EC 2.7.1.37   *Mitogen-Activated Protein Kinases *Schizosaccharomyces pombe Proteins. Mol Biol Cell 2006 Dec;17(12):5028-37
MKP1 protein, Arabidopsis  EC 2.7.1.-   *Mitogen-Activated Protein Kinases *Arabidopsis Proteins.
SRK1 protein, S pombe  EC 2.7.1.-   *Mitogen-Activated Protein Kinases *Schizosaccharomyces pombe Proteins.
MOK protein, human  EC 2.7.11.22   *Antigens, Neoplasm *Mitogen-Activated Protein Kinases.
Stk30 protein, mouse  EC 2.7.1.-   *Mitogen-Activated Protein Kinases.
Spk1 protein, S pombe  EC 2.7.1.37   *Mitogen-Activated Protein Kinases *Schizosaccharomyces pombe Proteins. Mol Cell Biol 2005 Mar;25(5):2045-59
mapk14a protein, Xenopus  EC 2.7.1.-   *Mitogen-Activated Protein Kinases *Xenopus Proteins.
nemo-like kinase, zebrafish  EC 2.7.1.37   *Mitogen-Activated Protein Kinases. Development 2004 Jun;131(12):2899-909
mitogen-activated protein kinase 11, mouse  EC 2.7.1.37   *Mitogen-Activated Protein Kinases. Biochem J 2004 Apr 1;379(Pt 1):133-9
NLK protein, human  EC 2.7.1.-   *Protein-Serine-Threonine Kinases *Intracellular Signaling Peptides and Proteins Mitogen-Activated Protein Kinases. Mol Cell Biol 2003 Jan;23(1):131-9
Pmk-1 protein, C elegans  0   *Mitogen-Activated Protein Kinases *Caenorhabditis elegans Proteins. Mol Cell Biol Res Commun 2001 Nov;4(6):337-44
nemo like kinase, Xenopus  EC 2.7.10.-   *Mitogen-Activated Protein Kinases. Genes Cells 2002 May;7(5):487-96
os-2 protein, Neurospora crassa  EC 2.7.1.-   *Fungal Proteins *Mitogen-Activated Protein Kinases. Appl Environ Microbiol 2002 Feb;68(2):532-8
unc-16 protein, C elegans  0   *Caenorhabditis elegans Proteins *Adaptor Proteins, Signal Transducing Mitogen-Activated Protein Kinases Vesicular Transport Proteins. Neuron 2001 Dec 6;32(5):787-800
pmk-3 protein, C elegans  EC 2.7.1.-   *Mitogen-Activated Protein Kinases *Caenorhabditis elegans Proteins. Mol Cell Biol Res Commun 2001 Nov;4(6):337-44
pmk-2 protein, C elegans  EC 2.7.1.-   *Mitogen-Activated Protein Kinases *Caenorhabditis elegans Proteins. Mol Cell Biol Res Commun 2001 Nov;4(6):337-44
Smk1 protein, S cerevisiae  EC 2.7.1.-   *Mitogen-Activated Protein Kinases *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2002 Jan;22(1):57-68
ubc2 protein, Ustilago maydis  0   *Fungal Proteins *Mitogen-Activated Protein Kinases. Mol Microbiol 2001 Sep;41(6):1365-79
JNK-1 protein, C elegans  EC 2.7.10.-   *Mitogen-Activated Protein Kinases *Caenorhabditis elegans Proteins. EMBO J 2001 Sep 17;20(18):5114-28
MPK6 protein, Arabidopsis  EC 2.7.1.-   *Mitogen-Activated Protein Kinases *Arabidopsis Proteins. Plant Physiol 2001 Aug;126(4):1579-87
AtMPK4 protein, Arabidopsis  EC 2.7.1.-   *Mitogen-Activated Protein Kinases *Arabidopsis Proteins. Cell. 2000 Dec 22;103(7):1111-20; Plant Physiol 2001 Aug;126(4):1579-87
Fmk1 protein, Fusarium oxysporum  EC 2.7.1.-   *Fungal Proteins *Mitogen-Activated Protein Kinases. Mol Microbiol 2001 Mar;39(5):1140-52
Pim1 MAP kinase  EC 2.7.1.-   *Mitogen-Activated Protein Kinases. Mol Genet Genomics 2001 Jun;265(4):604-14
MK1 protein, Capsicum annuum  EC 2.7.1.-   *Plant Proteins *Mitogen-Activated Protein Kinases. Mol Cells 2001 Feb 28;11(1):48-54
p43Ntf6MAP kinase, Nicotiana tabacum  EC 2.7.1.-   *Plant Proteins *Mitogen-Activated Protein Kinases. J Biol Chem 2001 May 25;276(21):18139-45
RISK-1  EC 2.7.1.-   *Mitogen-Activated Protein Kinases. J Neurobiol 2001 Apr;47(1):67-79
Ptk1 protein, Pyrenophora teres  EC 2.7.1.-   *Fungal Proteins *Mitogen-Activated Protein Kinases. Mol Plant Microbe Interact 2001 Feb;14(2):116-25
salt stress-induced MAP kinase  EC 2.7.1.-   *Plant Proteins *Mitogen-Activated Protein Kinases. Plant Cell 2000 Nov;12(11):2247-58
cmk1 protein, Colletotrichum lagenarium  EC 2.7.1.-   *Fungal Proteins *Mitogen-Activated Protein Kinases. Mol Plant Microbe Interact 2000 Apr;13(4):374-83
PK6 protein, Plasmodium falciparum  EC 2.7.1.-   *Protozoan Proteins *Cyclin-Dependent Kinases *Mitogen-Activated Protein Kinases. Biochem J 2000 Apr 1;347 Pt 1:255-63
Nlk protein, mouse  EC 2.7.10.-   *Mitogen-Activated Protein Kinases.
kpp2 protein, Ustilago maydis  EC 2.7.10.-   *Fungal Proteins *Mitogen-Activated Protein Kinases. Mol Microbiol 1999 Dec;34(5):1007-17
BWMK1 protein, Oryza sativa  EC 2.7.1.-   *Plant Proteins *Mitogen-Activated Protein Kinases. Mol Plant Microbe Interact 1999 Dec;12(12):1064-73
ZmMPK5  EC 2.7.1.-   *Mitogen-Activated Protein Kinases Plant Proteins. Mol Gen Genet 1999 Oct;262(3):534-42
Chk1 protein, Cochliobolus  EC 2.7.1.-   *Fungal Proteins *Mitogen-Activated Protein Kinases. Proc Natl Acad Sci U S A 1999 Nov 9;96(23):13542-7
RWJ 67657  0   *Imidazoles *Pyridines Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Pharmacol Exp Ther 1999 Nov;291(2):680-7
map-2 protein, Plasmodium falciparum  EC 2.7.10.-   *Protozoan Proteins *Mitogen-Activated Protein Kinases. J Biol Chem 1999 Oct 15;28812-20
WCK-1 protein, Triticum aestivum  EC 2.7.1.-   *Plant Proteins *Mitogen-Activated Protein Kinases. Plant Mol Biol 1999 Aug;40(6):921-33
WIPK protein, Nicotiana tabacum  0   *Plant Proteins *Mitogen-Activated Protein Kinases. Proc Natl Acad Sci U S A 1998 Jun 23;95(13):7433-8
nemo protein, Drosophila  EC 2.7.10.-   *Mitogen-Activated Protein Kinases *Drosophila Proteins. Cell 1994 Jul;78(1):125-36
SA-induced protein kinase  EC 2.7.10.-   *Mitogen-Activated Protein Kinases. Plant Cell 1997 May;9(5):809-24
Pmk1 protein, Magnaporthe grisea  EC 2.7.1.-   *Fungal Proteins *Mitogen-Activated Protein Kinases. Genes Dev 1996 Nov 1;10(21):2696-706
MMK4 kinase  EC 2.7.10.-   *Mitogen-Activated Protein Kinases. Nature 1996 Oct 10;383(6600):489-90
MMK2 protein, Medicago sativa  EC 2.7.10.-   *Plant Proteins *Mitogen-Activated Protein Kinases. Mol Gen Genet 1995 Oct 25;248(6):686-94
sty1 protein, S pombe  EC 2.7.1.-   *Mitogen-Activated Protein Kinases *Schizosaccharomyces pombe Proteins. Genes Dev 1995 Sep 1;9(17):2117-30
MKC1 protein, Candida albicans  EC 2.7.10.-   *Fungal Proteins *Mitogen-Activated Protein Kinases. Mol Cell Bioo 1995 Apr;15(4):2197-206
HOG1 protein, S cerevisiae  EC 2.7.10.-   *Mitogen-Activated Protein Kinases *Saccharomyces cerevisiae Proteins. Science 1994 Aug 5;265(5173):806-8
MPK2 protein, Arabidopsis  EC 2.7.10.-   *Mitogen-Activated Protein Kinases *Arabidopsis Proteins. Plant J 1994 Jan;5(1):111-122
ATMPK1 protein, Arabidopsis  EC 2.7.10.-   *Mitogen-Activated Protein Kinases *Arabidopsis Proteins. Plant J 1994 Jan;5(1):111-122
NTF3 protein, Nicotiana tabacum  EC 2.7.1.-   *Plant Proteins *Mitogen-Activated Protein Kinases Protein-Serine-Threonine Kinases. Plant Mol Biol 1993 Nov;23(3):543-51
MMK1 protein, Medicago sativa  EC 2.7.10.-   *Plant Proteins *Mitogen-Activated Protein Kinases. Plant J 1993 Apr;3(4):611-7
FUS3 protein, S cerevisiae  EC 2.7.11.24   *Mitogen-Activated Protein Kinases *Saccharomyces cerevisiae Proteins. Genes Dev 1992 Jul;6(7):1280-92
SLT2 protein, S cerevisiae  EC 2.7.11.24   *Mitogen-Activated Protein Kinases *Saccharomyces cerevisiae Proteins. Mol Microbiol 1991 Nov;5(11):2845-54
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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