Definition: A cytochrome P-450 monooxygenase that can be induced by polycyclic aromatic xenobiotics in the liver of human and several animal species. This enzyme is of significant clinical interest due to the large number of drug interactions associated with its induction and its metabolism of THEOPHYLLINE. Caffeine is considered to be a model substrate for this enzyme. CYP1A2 activity can also be increased by environmental factors such as cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole.
do not confuse with other cytochrome P-450 CYP's
Other names Phenacetin O Dealkylase; O-Dealkylase, Phenacetin; Demethylase, Caffeine; Cytochrome P 450d; Cytochrome P 450 CYP1A2; CYP1A2, Cytochrome P-450; Cytochrome P450 1A2; Cytochrome P-450d; Cytochrome P-450 LM4; Cytochrome P-450 LM(4); Caffeine Demethylase; CYP 1A2; Phenacetin O-Dealkylase; CYP1A2
