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Excitatory Amino Acid Antagonists

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Definition: Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.  GEN or unspecified; prefer specifics; DF: EAA ANTAG    Other names Receptor Antagonists, Glutamate; Antagonists, Glutamate Receptor; Antagonists, Glutamate; Antagonists, EAA; Glutamate Receptor Antagonists; EAA Antagonists; Antagonists, Excitatory Amino Acid; Amino Acid Antagonists, Excitatory; Glutamate Antagonists; Amino Acids, Excitatory, Antagonists
Substances having this pharmacologic action: ifenprodil; 2,3-piperidinedicarboxylic acid; 2-amino-7-phosphonoheptanoic acid; gabapentin; HA 966; caroverine; 2-amino-3-phosphonopropionic acid; Dizocilpine Maleate; Kynurenic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; 2-Aminoadipic Acid; 2-Amino-5-phosphonovalerate; Riluzole; Memantine; Phencyclidine; Phenobarbital; Ibogaine; Ketamine; Dextromethorphan; Dextrorphan; glutamic acid diethyl ester; ketobemidone; LY 341495; 6-methyl-2-(phenylethynyl)pyridine; licostinel; L 701324; 1-aminoindan-1,5-dicarboxylic acid; GV 150526A; 3,5-dihydroxyphenylglycine; GYKI 53655; 4-carboxyphenylglycine; alpha-methyl-4-carboxyphenylglycine; aptiganel; 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione; LY 235959; CGP 39653; gacyclidine; 4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline; NPC 12626; GYKI 52466; HU 211; 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; conantokin-T; 2-amino-4-methyl-5-phosphono-3-pentenoic acid; CGP 39551; SDZ EAA 494; 5,7-dichlorokynurenic acid; selfotel; conotoxin GV; FG 9041; 7-chlorokynurenic acid; eliprodil; carbinoxamine, dextromethorphan, pseudoephedrine drug combination; 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
lamotrigine  84057-84-1   *Triazines Analgesics Bipolar Disorder Cleft Lip Excitatory Amino Acid Antagonists Antimanic Agents.
Pharma Action Anticonvulsants ; Calcium Channel Blockers
Br J Clin Pharmacol 1985;20(6):619LAMICTAL CD; LAMICTAL; LAMOTRIGINE; LAMICTAL XR; LAMICTAL ODT

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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