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NAD(P)H Dehydrogenase (Quinone)

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Definition: A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.     
Examples zeta-Crystallins 		Other names Vitamin K Reductase; Quinone Reductase; Phylloquinone Reductase; Menadione Reductase; DT Diaphorase; Reductase, Vitamin K; Reductase, Quinone; Reductase, Phylloquinone; Reductase, Menadione; Diaphorase, DT
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-bromo-1-hydroxyphenazine  0   *Phenazines NAD(P)H Dehydrogenase (Quinone). J Med Chem 2010 Dec 23;53(24):8688-99
N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide  0   *Pyridines *Pyrrolizidine Alkaloids NAD(P)H Dehydrogenase (Quinone)/antagonists & inhibitors. Chem Biol Interact 2010 Jul 30;186(2):103-9
CBR4 protein, human  EC 1.6.5.2   *NAD(P)H Dehydrogenase (Quinone) *Mitochondrial Proteins. Biochem Biophys Res Commun 2008 Dec 26;377(4):1326-30
NQO1 protein, rat  EC 1.6.99.2   *NAD(P)H Dehydrogenase (Quinone). J Biol Chem 1986 Nov 25;261(33):15794-9
Nqo1 protein, mouse  EC 1.6.5.2   *NAD(P)H Dehydrogenase (Quinone).
NQO1 protein, human  EC 1.6.99.2   *NAD(P)H Dehydrogenase (Quinone).
5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione  0   *Indolequinones NAD(P)H Dehydrogenase (Quinone). Biochemistry 2001 Dec 18;40(50):15135-42
7-(2-aminoethyl)-5-hydroxy-1,4-benzothiazine  0   *Thiazines NAD(P)H Dehydrogenase (Quinone)/antagonists & inhibitors. J Neurochem 1998 Nov;71(5):2049-62
pterulone  0   *Benzofurans *Oxepins NAD(P)H Dehydrogenase (Quinone)/antagonists & inhibitors. J Antibiot (Tokyo) 1997 Apr;50(4):330-3
pterulinic acid  0   *Benzofurans *Oxepins NAD(P)H Dehydrogenase (Quinone)/antagonists & inhibitors. J Antibiot (Tokyo) 1997 Apr;50(4):330-3
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one  480-11-5   *Flavonoids NAD(P)H Dehydrogenase (Quinone)/antagonists & inhibitors. Arch Biochem Biophys 1993 Apr;302(1):72-7

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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