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Aflatoxin B1

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Definition: A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.  /antag permitted but consider also ANTITOXINS; DF: AFB1   
Pharmacological Action Poisons 		Other names Aflatoxin B1, (6aR-cis)-Isomer, 2H-Labeled; Aflatoxin B1, (6aR-cis)-Isomer, 14C-Labeled; Aflatoxin B1 Dihydrochloride, (6aR-cis)-Isomer; Aflatoxin B; NSC-529592; HSDB-3453; Aflatoxin B1, cis(+,-)-Isomer; Aflatoxin B1, (6aR-cis)-Isomer, 3H-Labeled
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
8,9-dihydroxy-8,9-dihydro-aflatoxin B1  0   Aflatoxin B1/*analogs & derivatives Mutagens. Carcinogenesis. 1980 Jan;1(1):79-90
aflatoxin-B1-N7-guanine  0   Guanine/*analogs & derivatives Aflatoxin B1/*analogs & derivatives. Chem Res Toxicol 2006 Sep;19(9):1191-5
aflatoxin B1-8,9-dihydrodiol-Tris buffer complex  0   Aflatoxin B1/*analogs & derivatives. Teratology 1994 Oct;50(4):311-7
aflatoxin B1-8,9-dichloride  119718-03-5   Aflatoxin B1/*analogs & derivatives. Mutat Res 1992 May;273(3):243-51
aflatoxin B1-DNA adduct  0   *Aflatoxin B1 *DNA Adducts. In Vivo 1989 Nov-Dec;3(6):389-92
aflatoxin B1-lysine adduct  0   *Lysine *Aflatoxin B1. Carcinogenesis 1990;11(11):2063
aflatoxin B1-(O-carboxymethyl)oxime  60484-26-6   Aflatoxin B1/*analogs & derivatives. Vet Hum Toxicol 1989;31(6):525
aflatoxin B1-formamidopyrimidine  65386-83-6   *Pyrimidines *Aflatoxin B1. Gastroenterology 1989;97(5):1281
aflatoxin B1-bovine serum albumin  0   *Aflatoxin B1 *Serum Albumin. Carcinogenesis 1987;8(6):819
8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1  68385-50-2   Glutathione/*analogs & derivatives Aflatoxin B1/*analogs & derivatives. Chem Biol Interact 1985;55(1-2):139
2,3-dihydro-2,3-(N(5)-formyl-2',5',6'-triamino-4-oxo-N(5)-pyrimidyl)-3-hydroxyaflatoxin B(1)  83953-67-7 Formamide, N-(2,4-diamino-1,4,5,6-tetrahydro-6-oxo-5-pyrimidinyl)-N-(1,2,3,6a,8,9,9a,11-octahydro-9-hydroxy-4-methoxy-1,11-dioxocyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-8-yl)  Aflatoxin B1/*analogs & derivatives. Appl Environ Microbiol 1982;44(5):1159
2,3-dihydro-2-(N(7)-guanyl)-3-hydroxyaflatoxin B1  63425-04-7   Guanine/*analogs & derivatives Aflatoxin B1/*analogs & derivatives DNA Adducts. Cancer Res 1981;41(2):650
2,3-dihydro-2,3-dihydroxyaflatoxin B(1)  50668-79-6 Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,8,9,9a-hexahydro-8,9-dihydroxy-4-methoxy-, (6aS-(6aalpha,8beta,9alpha,9aalpha))  Aflatoxin B1/*analogs & derivatives. Biochem Biophys Res Comm 53(4):1260;1973
aflatoxin B1-2,3-oxide  42583-46-0 Cyclopent(c)oxireno(4',5')furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,10-dione, 2,3,6a,7a,8a,8b-hexahydro-4-methoxy  Aflatoxin B1/*analogs & derivatives.
Pharma Action Carcinogens 		Biochem Biophys Res Comm 60(3):1036;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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