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Endothelins

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Definition: 21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.  GEN or unspecified; prefer specifics; /drug eff permitted   
See Also Receptors, Endothelin
Examples Endothelin-1; Endothelin-2; Endothelin-3 		Other names Endothelium-Derived Vasoconstrictor Factors; Vasoconstrictor Factors, Endothelium-Derived; Endothelin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
endothelin7-21(Leu7,Aib11,Cys(Acm)15)  0   *Peptide Fragments *Endothelins. Protein Eng 2002 Mar;15(3):161-7
TBC 3214  0   *Isoxazoles *Sulfonamides Endothelins/antagonists & inhibitors. J Med Chem 2001 Apr 12;44(8):1211-6
cyclo(tryptophyl-aspartyl-prolyl-thianylglycyl-leucyl)  0   *Peptides, Cyclic Endothelins/antagonists & inhibitors. J Pharmacol Exp Ther 1999 Feb;288(2):568-74
methylendioxyphenyl  0   *Dioxoles Endothelins/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Jan 6;8(1):11-6
cyclo(tryptophyl-aspartyl-acetyl(3)c-valyl-leucyl)  0   *Peptides, Cyclic Endothelins/antagonists & inhibitors. Int J Pept Protein Res 1996 Sep;48(3):229-39
cyclo(leucyl-valyl-prolyl-aspartyl-tryptophan)  0   *Peptides, Cyclic Endothelins/antagonists & inhibitors. Int J Pept Protein Res 1996 Sep;48(3):229-39
endothelin-1,2-6-keto-PGF1-alpha  0   *Endothelins 6-Ketoprostaglandin F1 alpha/*analogs & derivatives. Pol Arch Med Wewn 1996 Jun;95(6):509-13
preproendothelin 2  0   *Protein Precursors *Endothelins. Eur J Endocrinol 1996 Apr;134(4):490-6
IRL 1720  0   *Peptide Fragments *Endothelins Receptors, Endothelin/agonists. Eur J Pharmacol 1996 Jan 18;296(1):55-63
big endothelin-1 (19-37), Phe(22)  0   *Peptide Fragments *Endothelins. J Cardiovasc Pharmacol 1995;26 Suppl 3:S72-4
endothelin-3 (1-41)amide  0   *Peptide Fragments *Protein Precursors Endothelins. J Pharmacol Exp Ther 1995 Oct;275(1):120-6
endothelin-1, Ala(9)  0   Endothelins Receptors, Endothelin/antagonists & inhibitors. Eur J Pharmacol 1995 May 15;278(2):103-9
9-fluorenylmethoxycarbonyl-leucyl-aspartyl-isoleucyl-isoleucyl-tryptophan-OH  0   *Fluorenes *Oligopeptides Endothelins. Folia Biol (Praha) 1995;41(2):97-105
big endothelin-1(16-38), valine(22)  0   *Endothelins. FEBS Lett 1994 Oct 10;353(1):84-8
endothelin-1, Thr(18)-gamma-methyl-Leu(19)  0   Endothelins Receptors, Endothelin/antagonists & inhibitors. J Cardiovasc Pharmacol 1993;22 Suppl 8:S107-10
endothelin 1, Dpr(1)-Asp(15)  0   *Endothelins. J Appl Physiol 1993 May;74(5):2537-42
big-endothelin (16-32)  0   *Endothelins. Pept Res 1993 Mar-Apr;6(2):73-8
proendothelin-1 (31-38)  0   *Peptide Fragments *Endothelins Protein Precursors. J Hypertens 1992 Nov;10(11):1379-86
proendothelin 3  0   *Protein Precursors *Endothelins. Br J Pharmacol 1992 Oct;107(2):584-90
proendothelin 2  0   *Protein Precursors *Endothelins. Br J Pharmacol 1992 Oct;107(2):584-90
Cys(11)-Cys(15)-endothelin-1 (11-21)  144602-02-8 Endothelin 1-(pig reduced), 1-de-L-cysteine-2-de-L-serine-3-de-L-cysteine-4-de-L-serine-5-de-L-serine-6-de-L-leucine-7-de-L-methionine-8-de-L-aspartic acid-9-de-L-lysine-10-de-L-glutamic acid-, cyclic (11-15)-disulfide  *Peptide Fragments *Endothelins. FEBS Lett 1992 Oct 12;311(1):12-6
BQ 3020  143113-45-5 Endothelin 1 (pig reduced), 1-de-L-cysteine-2-de-L-serine-3-de-L-cysteine-4-de-L-serine-5-de-L-serine-6-(N-acetyl-L-leucine)-11-L-alanine-15-L-alanine  *Peptide Fragments *Endothelins. Life Sci 1992;51(6):47-52
preproendothelin-3  147994-89-6   *Protein Precursors *Endothelins. Biochem Biophys Res Commun 1992 Jul 15;186(1):588-94
big-endothelin (1-22)  0   *Endothelins. Biochem Int 1992 Jun;27(1):1-8
IRL 1620  142569-99-1   *Peptide Fragments *Endothelins. Biochem Biophys Res Commun 1992 Apr 30;184(2):953-9
endothelin-1, Pro(12)  0   Endothelins. Biochem Biophys Res Commun 1992 Mar 16;183(2):572-6
endothelin (16-21) amide  122855-39-4   *Peptide Fragments *Endothelins. Br J Pharmacol 1991 Oct;104(2):311-20
proendothelin-1 (22-39)  0   *Peptide Fragments *Protein Precursors *Endothelins. Br J Pharmacol 1991 Oct;104 (2):311-20
N(epsilon)-9-azidobenzoyliodoendothelin-1  0   *Azides *Endothelins. Mol Cell Endocrinol 1991;79(1-3):85
endothelin, Nle(7)  134699-39-1   *Endothelins. Int J Pept Protein Res 1991;37(4):315
endothelin 1, Ala(1,3,11,15)  121204-87-3   *Endothelins Endothelium, Vascular. Br J Pharmacol 1989;98(2):685
endothelin 1, Ala(3,11)  121185-73-7   *Endothelins Endothelium, Vascular. Br J Pharmacol 1989;98(2):669
endothelin 1, Ala(1,15)  121185-72-6   *Endothelins Endothelium, Vascular. Br J Pharmacol 1989;98(2):669
endothelin (16-21)  121377-67-1   *Peptide Fragments *Endothelins. Eur J Pharmacol 1989;166(1):121

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