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Ofloxacin

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Definition: A synthetic fluoroquinolone (FLUOROQUINOLONES) antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.     
Pharmacological Action Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Nucleic Acid Synthesis Inhibitors 		Other names Levofloxacin; Ru43280; Ru 43280; ORF28489; ORF 28489; Hoe280; Hoe 280; DR3355; DR 3355; DL8280; DL 8280; Tarivid; Ru-43280; Quixin; Ofloxacine; Ofloxacin, (S)-Isomer; Ofloxacin Hydrochloride; ORF-28489; Levaquin; Hoe-280Drugs* : FLOXIN IN DEXTROSE 5% IN PLASTIC CONTAINER; LEVOFLOXACIN; FLOXIN; OFLOXACIN; LEVAQUIN IN DEXTROSE 5% IN PLASTIC CONTAINER; OCUFLOX; QUIXIN; LEVOFLOXACIN; DEXTROSE; FLOXIN OTIC; LEVOFLOXACIN IN DEXTROSE 5% IN PLASTIC CONTAINER; IQUIX; FLOXIN IN DEXTROSE 5%; LEVAQUIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
antofloxacin  0   Ofloxacin/*analogs & derivatives. Xenobiotica 2007 Jun;37(6):579-91
R 71762  0   Ofloxacin/*analogs & derivatives. Chemotherapy 1999 Jan-Feb;45(1):48-55
ofloxacin pivaloyloxymethyl ester  150871-00-4 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (+-)  Ofloxacin/*analogs & derivatives. Biol Pharm Bull 1993 Jun;16(6):594-9
ofloxacin O-glucuronide  90293-81-5   Ofloxacin/*analogs & derivatives. Xenobiotica 1992 Apr;22(4):439-50
desmethylofloxacin  82419-46-3   Ofloxacin/*analogs & derivatives. Drugs 1987;34 Suppl 1:56
ofloxacin N-oxide  90318-77-7   Ofloxacin/*analogs & derivatives. Drugs 1987;34 Suppl 1:56
3-fluoromethyl ofloxacin  113472-55-2   Ofloxacin/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1987;35(5):1896

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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