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Venturicidins

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Definition: Toxic substances isolated from various strains of Streptomyces. They are 20-membered macrolides that inhibit oxidative phosphorylation and mitochondrial ATPases. Venturicidins A and B are glycosides. Used mainly as tools in the study of mitochondrial function.  uncoupling agents & antifungal antibiotics; from Streptomyces   
Pharmacological Action Antifungal Agents; Uncoupling Agents
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
venturicidin  11021-88-8   *Venturicidins Adenosine Triphosphatases/antagonists & inhibitors. J Biol Chem 2001 May 4;276(18):15269-74
venturicidin A  33538-71-5   *Venturicidins. Yakugaku Zasshi 1990;110(11):789
venturicidin B  33538-72-6 Venturicidin B  *Venturicidins. Yakugaku Zasshi 1990;110(11):790

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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