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Tetanus Toxin

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Definition: Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.  /antag permitted but consider also TETANUS ANTITOXIN   
Pharmacological Action Neurotoxins
See Also Tetanus Antitoxin 		Other names Clostridium tetani Toxin; Clostridial Neurotoxin; Toxins, Tetanus; Toxin, Tetanus; Toxin, Clostridium tetani; Neurotoxin, Clostridial; Tetanus Toxins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
tetanus toxin (947-966)  0   *Peptide Fragments *Tetanus Toxin. Eur J Immunol 2010 Apr;40(4):986-97
TNTCFP protein  0   *Recombinant Fusion Proteins Tetanus Toxin Green Fluorescent Proteins. J Neurosci 2005 Jul 6;25(27):6379-88
3-(2-amino-1-sulfanylethyl)benzenesulfonamide  0   *Sulfhydryl Compounds *Sulfonamides Metalloendopeptidases/antagonists & inhibitors Tetanus Toxin/antagonists & inhibitors. J Med Chem 1998 Aug 27;41(18):3450-60
zinc-endopeptidase, tetanus neurotoxin  EC 3.4.24.-   *Metalloendopeptidases *Tetanus Toxin. Eur J Biochem 1995 Apr 1;229(1):61-9
P30 tetanus toxin peptide  0   *Peptide Fragments *Tetanus Toxin Antigens. Eur J Immunol 1995 Jan;25(1):30-6
azo-GnRH tetanus toxoid conjugate  0   *Gonadotropin-Releasing Hormone *Tetanus Toxin. Indian J Exp Biol 1988;26(4):252
tetanus toxin fragment BIIb  0   *Peptide Fragments *Tetanus Toxin. Toxicon 1986;24(11-12):1055
tetanus toxin fragment C  0   *Peptide Fragments *Tetanus Toxin Toxins, Biological.
Pharma Action Neuromuscular Blocking Agents 		J Pharmacol Exp Ther 1984;228(3):600
tetanospasmin  11032-48-7   *Metalloendopeptidases *Tetanus Toxin. Vestn Khir 1982;129(10):144
tetanus toxin receptor  0   *Membrane Proteins Tetanus Toxin. J Biol Chem 1981;256(5):2402
tetanolysin  61614-31-1   *Tetanus Toxin. Biochim Biophys Acta 455:876;1976; Biochim Biophys Acta 551(1):224;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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