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Streptozocin

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Definition: An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.     
Pharmacological Action Antibiotics, Antineoplastic 		Other names Streptozotocin; Streptozocin Teva Brand; Zanosar; Teva Brand of Streptozocin; Streptozotocine; 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glDrugs* : ZANOSAR
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4,6-ethylidene glucose streptozotocin  121230-21-5   Streptozocin/*analogs & derivatives. Mol Cell Endocrinol 1989;62(2):153
SCAB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Doxorubicin Lomustine Streptozocin. J Cancer Res Clin Oncol 1988;114(1):105
FSM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Mitomycins Streptozocin. Cancer 1986;57(1):29
3-O-methyl-2-(((methylnitrosoamino)carbonyl)amino)glucopyranose  100821-69-0   Streptozocin/*analogs & derivatives. Diabetes 1985;35(1):74
3-(3-(2-chloroethyl)-3-nitrosoureido)-3-deoxyallose  81428-46-8   Streptozocin/*analogs & derivatives. Cancer Chemother Pharmacol 1984;13(1):22
3-(3-(2-chloroethyl)-3-nitrosourea)-3-deoxyglucopyranose  73237-82-8   Streptozocin/*analogs & derivatives. Cancer Chemother Pharmacol 1984;13(1):22
MOF-Strep protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Semustine Streptozocin Vincristine. J Clin Oncol 1983;1(1):135
FAM-S protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Fluorouracil Streptozocin Mitomycin. Am J Clin Oncol 1982;5(5):555
3 beta-D-glucopyranosyl-1-methyl-1-nitrosourea  37793-17-2 N'-beta-D-glucopyranosyl-N-methyl-N- nitrosourea  Streptozocin/*analogs & derivatives. Cancer Res 39(1):82;1979
GANU  58484-07-4 N-(2-chloroethyl)-N'-beta-D-glucopyranosyl-N-nitrosourea  Streptozocin/*analogs & derivatives. Cancer Res 37(3):783;1977; Gann 68(6):819;1977
U-30,964  41135-12-0 deoxy-2-(((ethylnitrosoamino)carbonyl)amino)-D-glucopyranose  Streptozocin/*analogs & derivatives. Biochem Pharmacol 24(6):746;1975
chlorozotocin  54749-90-5 2-((((2-chloroethyl)nitrosoamino)-carbonyl)amino)-2-deoxy-D-glucose  Streptozocin/*analogs & derivatives.
Pharma Action Antineoplastic Agents ; Carcinogens 		Biochem Pharmacol 26:2331;1977; Cancer 40(5) suppl:2640;1977; Cancer 43(6):2189;1979; Cancer Chemother Pharmacol 1(1):15;1978; Cancer Chemother Pharmacol 1979;3(4):217; Cancer Res 1980;40(1):50; Cancer Res 37(3):783;1977; Cancer Res 37(8):2615;1977; Cancer Treat Rep 1979;63(8):1409; Cancer Treat Rep 60(6):699;1976; Cancer Treat Rep 60(6):801;1976; Cancer Treat Rep 62(1):31;1978; Cancer Treat Rep 62(8):1145;1978; Cancer Treat Rep 63(1):17;1979; Clin Pharmacol Ther 23(6):712;1978; Dokl Akad Nauk SSSR 245(1):260;1979; J Clin Invest 1979;64(4):1103; J Med Assoc Ga 66(9):729;1977; J Med Chem 18(1):104;1975; J Med Chem 22(5):597;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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