Spleen Focus-Forming Viruses (definition)

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Spleen Focus-Forming Viruses

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Definition: Strains of MURINE LEUKEMIA VIRUS that are replication-defective and rapidly transforming. The envelope gene plays an essential role in initiating erythroleukemia (LEUKEMIA, ERYTHROBLASTIC, ACUTE), manifested by splenic foci, SPLENOMEGALY, and POLYCYTHEMIA. Spleen focus-forming viruses are generated by recombination with endogenous retroviral sequences.

infection: coordinate IM with RETROVIRIDAE INFECTIONS (IM) + TUMOR VIRUS INFECTIONS (IM) + LEUKEMIA, EXPERIMENTAL (IM) or LEUKEMIA, ERYTHROBLASTIC, ACUTE (IM) (for spontaneous erythroleukemia)

Other names Rauscher Spleen Focus-Forming Virus; Friend spleen focus-forming virus; Spleen Focus-Forming Virus; Spleen Focus Forming Viruses; Friend spleen focus forming virus; Focus-Forming Viruses, Spleen; Focus-Forming Virus, Spleen; SFFV

Substance	CAS Registry & name	Categories	Source
glycoprotein gp55, Friend spleen focus-forming virus	0	*Viral Envelope Proteins Membrane Glycoproteins Spleen Focus-Forming Viruses.	Blood 1992 Dec 15;80(12):3070-8
gp52 protein, spleen focus-forming virus	0	*Viral Envelope Proteins Spleen Focus-Forming Viruses.	J Virol. 1979 Jun;30(3):787-98.; Virus Res 1992 Oct;26(1):57-69

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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