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Receptors, Cholecystokinin

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Definition: Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes secretion of AMYLASE by pancreatic acinar cells, acid and PEPSIN by stomach mucosal cells, and contraction of the PYLORUS and GALLBLADDER. The role of the widespread CCK receptors in the central nervous system is not well understood.  DF: RECEPT CCK   
Examples Receptor, Cholecystokinin A; Receptor, Cholecystokinin B 		Other names Sincalide Receptors; Receptors, Sincalide; Receptors, Pancreozymin; Receptors, Caerulein; Receptors, CCK; Pancreozymin Receptors; Cholecystokinin Receptors; Cholecystokinin Octapeptide Receptors; Caerulein Receptors; CCK Receptors; CCK 8 Receptors; CCK 4 Receptors; Receptors, Cholecystokinin Octapeptide; Receptors, CCK-8; Receptors, CCK-4; Cholecystokinin Receptor; CCK-8 Receptors; CCK-4 Receptors; CCK Receptor; Receptors, CCK 8
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
tyrosyl-phenylalanyl-glycyl-tryptophyl-N-methylnorleucyl-aspartyl-phenylalaninamide  0   *Oligopeptides Receptors, Opioid, mu/agonists Receptors, Cholecystokinin/antagonists & inhibitors Receptors, Opioid, delta/agonists. Life Sci. 2003 Jun 27;73(6):699-704.
2-(2-((1H-indole-2-carbonyl)amino)benzoylamino)-4-phenylbutyric acid  0   *Aminobutyric Acids *Anthranilic Acids Receptors, Cholecystokinin/antagonists & inhibitors. J Med Chem. 2011 Aug 25;54(16):5769-85.
2-(5-cyclohexyl-1-(2-cyclopentyl-2-oxoethyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-N-(3-(5-oxo-2,5-dihydro-(1,2,4)oxadiazol-3-yl)phenyl)acetamide  0   *Benzodiazepines Receptors, Cholecystokinin/antagonists & inhibitors. J Med Chem 2007 Jun 28;50(13):3101-12
CCK1 protein, mouse  0   *Receptors, Cholecystokinin. Am J Physiol Regul Integr Comp Physiol 2008 Jan;294(1):R33-8
tyrosyl-norleucyl-glycyl-tryptophyl-norleucyl-aspartyl-phenylalaninamide  0   *Oligopeptides Receptors, Cholecystokinin/antagonists & inhibitors Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. J Med Chem 2006 May 18;49(10):2868-75
CCKLR-17D3 protein, Drosophila  0   *Receptors, Cholecystokinin *Drosophila Proteins. Biochem Biophys Res Commun 2002 Feb 22;291(2):313-20
2-benzyl-5-(N-(tert-butoxycarbonyl)tryptophyl)amino-3-oxo-1-thioxoperhydropyrido(1,2-c)pyrimidine  0   *Pyrimidinones Tryptophan/*analogs & derivatives Receptors, Cholecystokinin/antagonists & inhibitors. J Med Chem 2001 Nov 22;44(24):4196-206
2-(2-(5-bromo-1H-indol-3-yl)ethyl)-3-(1-methylethoxyphenyl)-4-(3H)-quinazolinone  0   *Quinazolinones Receptors, Cholecystokinin/antagonists & inhibitors. Neuroreport 2001 Aug 28;12(12):2717-20
fumiquinazoline A  0   *Quinazolines Receptors, Cholecystokinin/antagonists & inhibitors. Org Lett 2000 Dec 14;2(25):4103-6
fumiquinazoline B  0   *Quinazolines Receptors, Cholecystokinin. Org Lett 2000 Dec 14;2(25):4103-6
fumiquinazoline I  0   *Quinazolines Receptors, Cholecystokinin/antagonists & inhibitors. Org Lett 2000 Dec 14;2(25):4103-6
2-(benzyloxycarbonyl)amino-5-(1'-carboxy-2'-phenylethyl)carbamoyl-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino(8,7-b)indole  0   *Indoles *Indolizines Receptors, Cholecystokinin/antagonists & inhibitors. J Med Chem 2000 Oct 5;43(20):3770-7
malonyl-tryptophyl-(N-methyl)norleucyl-aspartyl-phenylalaninamide  0   *Oligopeptides Receptors, Cholecystokinin/antagonists & inhibitors. J Med Chem 2000 Oct 5;43(20):3614-23
PD 170292  0   Adamantane/*analogs & derivatives Citrulline/*analogs & derivatives Receptors, Cholecystokinin/agonists. Bioorg Med Chem Lett 2000 Jun 5;10(11):1245-8
N-(succinyl-Asp-2-phenylethylamido)-Trp-2-(2-naphthyl)ethylamide  0   *Oligopeptides Receptors, Cholecystokinin/antagonists & inhibitors. J Med Chem 2000 Sep 21;43(19):3505-17
4-hydroxyphenylacetyl-norleucyl-glycyl-tryptophyl-lysyl((((4-methylphenyl)sulfonyl)amino)carbonyl)-aspartyl-N-methylphenylalaninamide  0   *Oligopeptides Receptors, Cholecystokinin/agonists. J Med Chem 2000 Jun 15;43(12):2350-5
FR 208419  0   *Benzodiazepinones *Phenylurea Compounds Receptors, Cholecystokinin/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 2000 Jan;48(1):1-15
2-benzyl-5-(2-N-(tert-butylaminocarbonyl)amino-3-(indol-3-yl)propyl)amino-1,3-dioxoperhydropyrido(1,2-c)pyrimidine  0   *Pyridines *Pyrimidinones Receptors, Cholecystokinin/antagonists & inhibitors. J Med Chem 1999 Nov 4;42(22):4659-68
2-benzyl-5-(2-N-(2,2-dimethylpropylcarbonyl)amino-3-(indol-3-yl)propyl)amino-1,3-dioxoperhydropyrido(1,2-c)pyrimidine  0   *Pyridines *Pyrimidinones Receptors, Cholecystokinin/antagonists & inhibitors. J Med Chem 1999 Nov 4;2(22):4659-68
cholecystokinin (26-33), iodo-Tyr-Gly--Nle(28,31)-Bpa(33)  0   *Peptide Fragments Cholecystokinin/*analogs & derivatives Iodine Radioisotopes Ligands Receptors, Cholecystokinin/agonists. J Med Chem 1999 Jun 17;42(12):2105-11
cholecystokinin (26-33), iodo-Tyr-Gly-Nle(28,31)-Bpa(29-33)  0   *Peptide Fragments Cholecystokinin/*analogs & derivatives Iodine Radioisotopes Ligands Receptors, Cholecystokinin/agonists. J Med Chem 1999 Jun 17;42(12):2105-11
4-N-benzyl-2,3,4,5,6,7-hexahydro-1H-1,4,7-benzotriazonin-2,6-dione  0   *Triazines Receptors, Cholecystokinin/antagonists & inhibitors. J Pept Sci 1999 Mar;5(3):155-8
JMV 1155  0   *Organic Chemicals Receptors, Cholecystokinin/antagonists & inhibitors. Anticancer Res 1999 Jan-Feb;19(1A):45-50
SR 146131  0   *Indoles *Thiazoles Receptors, Cholecystokinin/agonists. J Pharmacol Exp Ther 1999 May;289(2):742-51
alanyl-tryptophyl-methionyl-aspartyl-phenylalanylamide  0   Pentagastrin/*analogs & derivatives Receptors, Cholecystokinin/drug effects. Ross Fiziol Zh Im I M Sechenova 1998 Oct;84(10):1100-7
2-((benzyloxycarbonyl)amino)-1,3a,4,5,10,10a-hexahydro-4-(1-phenylmethyl-2-carboxyethyl)indolo(3,2-e)indolizine-3(2H)-one  0   *Indoles *Indolizines Receptors, Cholecystokinin/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Jan 4;9(1):43-8
TS 941  0   *Benzodiazepines Receptors, Cholecystokinin/antagonists & inhibitors. Pancreas 1998 Oct;17(3):289-94
DA 3934  0   *Acetic Acids *Phenylurea Compounds Receptors, Cholecystokinin/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1998 Jun;46(6):951-61
DZ 3514  0   *Acetamides *Phenylurea Compounds Receptors, Cholecystokinin/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1998 Mar;46(3):434-44
GV 150013X  0   *Phenylurea Compounds Adamantane/*analogs & derivatives Receptors, Cholecystokinin/antagonists & inhibitors. Xenobiotica 1998 Feb;28(2):167-78
S 0509  0   *Benzophenones *Phenylurea Compounds Receptors, Cholecystokinin/antagonists & inhibitors. Bioorg Med Chem 1997 Aug;5(8):1695-714
CCK-C receptor  0   *Receptors, Cholecystokinin. Life Sci 1997;61(10):1009-18
RB 360  0   *Oligopeptides Cholecystokinin/agonists Receptors, Cholecystokinin/agonists Stereoisomerism. J Med Chem 1997 Feb 28;40(5):647-58
YF 476  0   *Benzodiazepinones *Phenylurea Compounds Receptors, Cholecystokinin/antagonists & inhibitors. J Med Chem 1997 Jan 31;40(3):331-41
CCK-X receptor  0   *Receptors, Cholecystokinin. Gen Comp Endocrinol 1996 Apr;102(1):61-73
T 0632  169042-78-8   *Indoles Receptors, Cholecystokinin/antagonists & inhibitors. Eur J Pharmacol 1996 May 23;304(1-3):147-54
PD 161182  0   Phenylalanine/*analogs & derivatives Receptors, Cholecystokinin/antagonists & inhibitors. Immunopharmacology 1996 Jun;33(1-3):68-72
TP 680  0   Cysteine/*analogs & derivatives Niacin/*analogs & derivatives Receptors, Cholecystokinin/antagonists & inhibitors. Br J Pharmacol 1996 Apr;117(7):1558-64
succinyl-tryptophyl-N-methyl-norleucyl-aspartyl-phenylalaninamide  0   *Oligopeptides Receptors, Cholecystokinin/agonists. Neuropeptides 1995 Nov;29(5):241-4
CAM 1481  0   *Dipeptides Receptors, Cholecystokinin/antagonists & inhibitors. Br J Pharmacol 1995 Oct;116(4):2274-8
8-sulfocholecystokinin octapeptide  0   Sincalide/*analogs & derivatives Receptors, Cholecystokinin/agonists.
Pharma Action Nootropic Agents 		Peptides 1994;15(4):689-97
A 71378  127902-33-4 L-Phenylalaninamide, N-(1-oxo-3-(4-(sulfooxy)phenyl)propyl)-L-norleucylglycyl-L-tryptophyl-L-norleucyl-N-methyl-L-alpha-aspartyl  *Oligopeptides Receptors, Cholecystokinin/agonists. Am J Physiol 1990;258(4 Pt 1):G648
L 365260  118101-09-0   *Benzodiazepinones *Phenylurea Compounds Receptors, Cholecystokinin/antagonists & inhibitors Stereoisomerism. J Med Chem 1989;32(1):13

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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