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Primaquine

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Definition: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)     
Pharmacological Action Antimalarials 		Other names Phosphate, Primaquine; Diphosphate, Primaquine; Primaquine Phosphate; Primaquine Diphosphate; Primacin; Boucher & Muir Brand of Primaquine PhosphateDrugs* : PRIMAQUINE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-tert-butylprimaquine  0   Primaquine/*analogs & derivatives. J Med Chem 2004 Jan 15;47(2):285-7
6-demethylprimaquine  0   Primaquine/*analogs & derivatives. Drug Metab Dispos 1995 Jan;23(1):18-27
bis(trifluoroacetyl)primaquine  93245-26-2   Primaquine/*analogs & derivatives. Yao Hsueh Hsueh Pao 1992;27(6):423-7
4-methyl-6-methoxy-8-(1-pentamethyleneamino)aminoquinoline  68219-12-5   Primaquine/*analogs & derivatives. Yao Hsueh Hsueh Pao 1992;27(6):418-22
4-methyl-6-methoxy-8-(1-tetramethyleneamino)aminoquinoline  68219-10-3   Primaquine/*analogs & derivatives. Yao Hsueh Hsueh Pao 1992;27(6):418-22
M 8506  93245-29-5   Primaquine/*analogs & derivatives. Chih 1990;8(4):259; Chung Kuo Chi Sheng Chung Hsueh Yu Chi Sheng Chung Ping Tsa
WR 242511  81358-96-5   Primaquine/*analogs & derivatives. Exp Parasitol 1991;72(4):
compound 80-53  0   Primaquine/*analogs & derivatives. Indian J Med Res 1989;89:330
5-hydroxyprimaquine  57695-07-5   Primaquine/*analogs & derivatives. Biochem Pharmacol 1988;37(13):2683
4-methyl-5-(4-fluorophenoxy)primaquine  80061-25-2   Primaquine/*analogs & derivatives Plasmodium yoelii. Yao Hsueh Hsueh Pao 1986;21(9):698
cysteinylprimaquine  102615-51-0   Primaquine/*analogs & derivatives. J Med Chem 1986;29(9):1765
WR 250016  87321-06-0 5,6-Quinolinediol, 8-((4-amino-1-methylbutyl)amino)-, trihydrobromide  Primaquine/*analogs & derivatives. Biochem Pharmacol 1986;36(7):1091
8-(3-carboxy-1-methylpropylamino)-6-methoxyquinoline  77229-68-6 Pentanoic acid, 4-((6-methoxy-8-quinolinyl)amino)  Primaquine/*analogs & derivatives. J Chromatogr 1982;230(1):69
octanoylprimaquine  81947-79-7 Octanamide, N-(4-((6-methoxy-8-quinolinyl)amino)pentyl)  Primaquine/*analogs & derivatives. Chung Huo Yao Li Hseuh Pao 1982;3(1):61

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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