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Mutation

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Definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.  drug-induced mutation   
See Also Antimutagenic Agents; DNA Damage; Mutagenesis; Mutagens; Polymorphism, Restriction Fragment Length; Suppression, Genetic
Examples Allelic Imbalance; Base Pair Mismatch; Chromosome Aberrations; Codon, Nonsense; DNA Repeat Expansion; Frameshift Mutation; Gene Amplification; Gene Duplication; Genomic Instability; Germ-Line Mutation; INDEL Mutation; Mutagenesis, Insertional; Mutation Rate; Mutation, Missense; Point Mutation; Sequence Deletion; Sequence Inversion; Suppression, Genetic 		Other names Mutations
 
SubstanceCAS Registry & nameCategoriesSource
APP717  0   *Amyloid beta-Protein Precursor Mutation. Neurosci Lett 1991 Aug 5;129(1):134-5
cystic fibrosis transmembrane conductance regulator delta F508  0   *Cystic Fibrosis Transmembrane Conductance Regulator Mutation. Am J Physiol 1995 Apr;268(4 Pt 1):L615-24

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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