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Methylenetetrahydrofolate Dehydrogenase (NADP)

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Definition: An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.  do not confuse with METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+)   
See Also Formate-Tetrahydrofolate Ligase; Methenyltetrahydrofolate Cyclohydrolase 		Other names Methylenetetrahydrofolate Dehydrogenase (NADP+); Dehydrogenase, Methylenetetrahydrofolate; Methylenetetrahydrofolate Dehydrogenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MTHFD1 protein, human  EC 1.5.1.5   *Methylenetetrahydrofolate Dehydrogenase (NADP). Hum Mutat 2009 Feb;30(2):212-20
5,6,7,8-tetrahydro-N(5),N(10)-carbonylfolic acid  0   Folic Acid/*analogs & derivatives Methylenetetrahydrofolate Dehydrogenase (NADP)/antagonists & inhibitors. J Pharmacol Exp Ther 1998 Oct;287(1):315-21
methylene tetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase  0   *Aminohydrolases *Methylenetetrahydrofolate Dehydrogenase (NADP) *Multienzyme Complexes. J Biol Chem 1988;263(10):4662
formyl-methenyl-methylenetetrahydrofolate synthetase  73699-18-0 Synthetase, formyl-methenyl-methylenetetrahydrofolate  *Aminohydrolases *Formate-Tetrahydrofolate Ligase *Methylenetetrahydrofolate Dehydrogenase (NADP) *Multienzyme Complexes. Adv Exp Med Biol 1983;163;75; Biochem Biophys Res Commun 77(1):147;1977; J Biol Chem 1980;255(6):2569; J Biol Chem 251(16):5104;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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