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1-Acylglycerophosphocholine O-Acyltransferase

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Definition: An enzyme localized predominantly within the plasma membrane of lymphocytes. It catalyzes the transfer of long-chain fatty acids, preferentially unsaturated fatty acids, to lysophosphatides with the formation of 1,2-diacylglycero-3-phosphocholine and CoA. EC 2.3.1.23.      Other names Lysolecithin Acyltransferase; Acyl CoA Lysolecithin Acyltransferase; 1-Acylglycerophosphocholine Acyltransferase; O-Acyltransferase, 1-Acylglycerophosphocholine; Lysophosphatidylcholine Palmitoyl CoA Acyltransfer; CoA Acyltransferase, Lysophosphatidylcholine-Palmi; Acyltransferase, Lysophospholipid; Acyltransferase, Lysophosphatidylcholine-Palmitoyl; Acyltransferase, Lysophosphatidylcholine; Acyltransferase, Lysolecithin; Acyltransferase, 1-Acylglycerophosphocholine; Acyl CoA 1 Acylglycero 3 Phosphocholine O Acyltran; 1 Acylglycerophosphocholine O Acyltransferase; 1 Acylglycerophosphocholine Acyltransferase; Lysophospholipid Acyltransferase; Lysophosphatidylcholine-Palmitoyl CoA Acyltransfer; Lysophosphatidylcholine Acyltransferase; Acyl-CoA-1-Acylglycero-3-Phosphocholine-O-Acyltran
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
LPCAT3 protein, human  EC 2.3.1.23   *1-Acylglycerophosphocholine O-Acyltransferase. Lipids. 2008 Oct;43(10):895-902
Lpcat1 protein, mouse  EC 2.3.1.23   *1-Acylglycerophosphocholine O-Acyltransferase. J Biol Chem 2006 Jul 21;281(29):20140-7
Lpcat1 protein, human  EC 2.3.1.23   *1-Acylglycerophosphocholine O-Acyltransferase. J Biol Chem 2006 Jul 21;281(29):20140-7
LPT1 protein, S cerevisiae  EC 2.3.1.23   *1-Acylglycerophosphocholine O-Acyltransferase *Saccharomyces cerevisiae Proteins. J Biol Chem 2007 Nov 23;282(47):34288-98
tafazzin protein, Drosophila  EC 2.3.1.23   *1-Acylglycerophosphocholine O-Acyltransferase *Drosophila Proteins. Proc Natl Acad Sci U S A 2006 Aug 1;103(31):11584-8
CI-976-sensitive lysophospholipid acyltransferase  EC 2.3.1.23   *1-Acylglycerophosphocholine O-Acyltransferase. Biochem Biophys Res Commun 2004 Jan 16;313(3):681-6

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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