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Glaucarubin

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Definition: (1 beta,2 alpha,11 beta,12 alpha,15 beta(S))-11,20-Epoxy-1,2,11,12-tetrahydroxy-15-(2-hydroxy-2-methyl-1-oxobutoxy)picras-3-en-16-one. A quassinoid (Simaroubolide) from Simaruba glauca, a tropical shrub. It has been used as an antiamebic agent and is found to be cytotoxic. It may be of use in cancer chemotherapy.     
Pharmacological Action Antineoplastic Agents, Phytogenic 		Other names Kirondrin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
glaucarubolone  1990-01-8   Glaucarubin/*analogs & derivatives Cell Transformation, Viral/drug effects. Biochem Biophys Res Commun 1980;93(3):675
13,18-dehydroglaucarubinone  68703-94-6 Picrasa-3,13(21)-diene-2,16-dione, 1,11,12-trihydroxy-15-(2-hydroxy-2-methyl-1-oxobutoxy)-, (1beta,11beta,12alpha,15beta(S))  Glaucarubin/*analogs & derivatives Simaroubaceae. Experientia 34(9):1122;1978
glaucarubinone  1259-86-5   Glaucarubin/*analogs & derivatives. Lloydia 40(4):364;1977

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