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G(M3) Ganglioside

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Definition: A ganglioside present in abnormally large amounts in the brain and liver due to a deficient biosynthetic enzyme, G(M3):UDP-N-acetylgalactosaminyltransferase. Deficiency of this enzyme prevents the formation of G(M2) ganglioside from G(M3) ganglioside and is the cause of an anabolic sphingolipidosis.  G(M3) gangliosidosis: coord NIM with GANGLIOSIDOSIS (IM)    Other names Sialyllactosylceramide; Hematoside; Lactosylceramide, Sialyl; GM3, Ganglioside; Sialyl Lactosylceramide; II3NeuAcLacCer; Ganglioside GM3
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-acetamido-3,4,5,8-tetradeoxy-lyxo-2-nonulopyranosylonic acid-2-3-galactopyranosyl-1-4-glucopyranosyl-(1-1)-2-octadecanamido-4-octadecene-1,3-diol  0   G(M3) Ganglioside/*analogs & derivatives. Carbohydr Res 1996 Jan 11;280(2):331-8
ganglioside GM3 lactam  0   G(M3) Ganglioside/*analogs & derivatives. Glycoconj J 1992 Dec;9(6):303-6
N-acetylneuraminosyl-2-6-galactosyl-1-4-glucopyranosyl-1-1-ceramide  0   G(M3) Ganglioside/*analogs & derivatives. Biosci Biotechnol Biochem 1992 Mar;56(3):535-6
lyso-G(M3) ganglioside  0   G(M3) Ganglioside/*analogs & derivatives. J Biol Chem 1988;263(22):10915
de-N-acetylneuraminyllactosylceramide  115082-64-9   G(M3) Ganglioside/*analogs & derivatives. J Biol Chem 1988;263(13):6296
4-O-acetyl-N-glycolylneuraminyl lactosylceramide  73379-75-6   *Antigens, Neoplasm G(M3) Ganglioside/*analogs & derivatives. Mol Immunol 1986;23(6):631
ganglioside GM3 lactone  99477-47-1   G(M3) Ganglioside/*analogs & derivatives. J Biochem (Tokyo) 1985;98(5):1367
N-glycolylneuraminyllactosylceramide  69345-49-9 Ganglioside GM3, N-deacetyl-N-(hydroxyacetyl)-, (5alpha,17alpha)  G(M3) Ganglioside/*analogs & derivatives. J Biol Chem 1985;260(3):1362

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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