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Amifostine

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Definition: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.  D25-26 qualif   
Pharmacological Action Radiation-Protective Agents 		Other names Gammaphos; Ethiofos; YM08310; YM 08310; WR2721; WR 2721; Schering Plough Brand of Amifostine; Salt, Amifostine Disodium; NSC296961; NSC 296961; Monohydrochloride, Amifostine; Monohydrate, Amifostine; Disodium Salt, Amifostine; Amifostine Schering-Plough Brand; Amifostine Lilly Brand; Amifostine Essex Brand; Amifostine Alza Brand; Acid, Aminopropylaminoethylthiophosphoric; YM-08310; WR-2721Drugs* : AMIFOSTINE; ETHYOL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
S-2 (4-aminobutylamino)ethylphenylsulfide  0   Amifostine/*analogs & derivatives. Toxicol Appl Pharmacol 2001 Oct 1;176(1):24-33
S-2 (2-aminoethylamino)ethylphenylsulfide  0   Amifostine/*analogs & derivatives. Toxicol Appl Pharmacol 2001 Oct 1;176(1):24-33
S-2 (3-aminopropylamino)ethylphenylsulfide  0   Amifostine/*analogs & derivatives. Toxicol Appl Pharmacol 2001 Oct 1;176(1):24-33
GAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Deoxycytidine/analogs & derivatives Amifostine. Anticancer Drugs 1998 Jul;9(6):511-4
ACV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Amifostine Vinblastine. J Clin Oncol 1996 Jun;14(6):1913-21
S-2-(3-methylaminopropylamino)ethylphosphorothioic acid  20751-90-0   Amifostine/*analogs & derivatives.
Pharma Action Radiation-Protective Agents 		Radiat Res 1986;106(3):366
WR 77913  58319-25-8   Amifostine/*analogs & derivatives.
Pharma Action Radiation-Sensitizing Agents 		Int J Radiat Oncol Biol Phys 1982;8(3-4):553

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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