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Digoxin

More information in Books or onNLM PubMed
Definition: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)  do not confuse with DIGITOXIN   
Pharmacological Action Anti-Arrhythmia Agents; Cardiotonic Agents; Enzyme Inhibitors
Examples Acetyldigoxins; Digoxigenin; Medigoxin 		Other names Nativelle, Hemigoxine; Nativelle, Digoxine; Lanoxin PG; Boehringer, Digoxina; Virco Brand of Digoxin; Teofarma Brand of Digoxin; Roche Brand of Digoxin; R.A.N. Brand of Digoxin; Proctor & Gamble Brand of Digoxin; Novartis Brand of Digoxin; UDL Brand of Digoxin; Mapluxin; Lilly Brand of Digoxin; Lenoxin; Lanoxin-PG; Lanoxin; Lanoxicaps; Lanicor; Lanacordin; Kern Brand of DigoxinDrugs* : LANOXIN PEDIATRIC; LANOXICAPS; DIGOXIN PEDIATRIC; DIGOXIN; LANOXIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
digoxin-21-salicylidene  0   Digoxin/*analogs & derivatives. Nature. 2011 Apr 28;472(7344):486-90
20,22-dihydrodigoxin-21,23-diol  0   Digoxin/*analogs & derivatives. Nature. 2011 Apr 28;472(7344):486-90
G3 PAMAM-NH2 dendrimer-modified digoxin  0   *Digoxin *Dendrimers Topoisomerase Inhibitors. Acta Pol Pharm. 2010 Nov-Dec;67(6):630-4
4-(3',15'-dihydroxy-5'-estran-17'-yl)furan-2-methyl alcohol  0   *Estranes Digoxin/antagonists & inhibitors. J Med Chem 2006 Jan 26;49(2):600-6
digoxin 2-methyl-4-(4-nitrobenzyl)perhydro-1,4-oxazepine  0   Digoxin/*analogs & derivatives. Steroids 1995 Nov;60(11):753-8
digoxin dialdehyde  0   Digoxin/*analogs & derivatives. Steroids 1995 Nov;60(11):753-8
digoxin-di-(2-hydroxy-3-methylbenzoylhydrazide) conjugate  0   Digoxin/*analogs & derivatives. Biol Pharm Bull 1994 Jan;17(1):97-101
digoxin 3'-hemisuccinate-bovine serum albumin conjugate  0   *Serum Albumin, Bovine Digoxin/*analogs & derivatives. Clin Chem 1994 Jan;40(1):172-3
digoxin-iodohistamine(bis(O-carboxymethyloxime))  142078-77-1   Digoxin/*analogs & derivatives Histamine/*analogs & derivatives. J Nucl Med 1992 Apr;33(4):545-9
digoxin-phosphatidylethanolamine conjugate  129966-52-5   *Phosphatidylethanolamines Digoxin/*analogs & derivatives. Bioconjug Chem 1990;1(5):309
digoxin antibodies Fab fragments  0   *Immunoglobulin Fab Fragments Digoxin/immunology. Arch Fr Pediatr 1986;43(4):293
deriphyllin-digoxin  0   *Digoxin Drug Combinations Theophylline/*analogs & derivatives Delayed-Action Preparations. Int J Clin Pharmacol Ther Toxicol 1986;24(1):30
digoxin-16'-glucuronide  68325-31-5   Digoxin/*analogs & derivatives. Basic Res Cardiol 1984;79(suppl):134
7-hydroxydigoxin  72908-79-3   Digoxin/*analogs & derivatives. Steroids 1981;38(1):11
cardiac glycoside receptors  0   *Sodium-Potassium-Exchanging ATPase Cardiac Glycosides Digoxin Ouabain. Biochem Pharmacol 1980;29(24):3219
digoxin, nicotinic acid, pentifylline drug combination  0   *Digoxin *Nicotinic Acids Drug Combinations Theobromine/*analogs & derivatives. Ther Ggw 1979;118(11):1704
gitaloxin  3261-53-8 (3 beta,5 beta,16 beta)-3- ((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)- O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-16-(formyl oxy)-14-hydroxycard-20(22)-enolide  Digoxin/*analogs & derivatives. Arch Int Pharmacodyn Ther 239(1):168;1979
SC 4453  59712-21-9 beta-D-ribo-Hexopyranoside, (3beta,5beta,12beta,14beta,17beta)-12,14-dihydroxy-17-(4-pyridazinyl)androstan-3-yl O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy  Digoxin/*analogs & derivatives Cardiac Glycosides. Arch Int Pharmacodyn Ther 239(1):171;1979
pentaformylgitoxin  10176-39-3 (3 beta,5 beta,16 beta)-3-((O-2,6-dideoxy-3,4-di-O-formyl- beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-3-O-formyl-beta-D-ribo-hexanopyranosyl-(1-4)-2,6-dide oxy-3-O-formyl-beta-D-ribo-hexanopyranosyl)oxy)- 16-(formyloxy)-14-hydroxycard-20(22)-enolide  Digoxin/*analogs & derivatives Isomerism. Arzneim Forsch 20(6):1201;1976; Int J Clin Pharmacol Biopharm 1979; 17(10):416; Rev Clin Esp 132(4):359;1974; Therapie 1979;34(2):255; Therapie 33(6):723;1978
gitoxin  4562-36-1   Digoxin/*analogs & derivatives. Acta Biol Med Germ 37(4):637;1978; Eur J Clin Pharmacol 1979;16(5):341; Europ J Clin Pharmacol 11:455;1977; Int J Clin Pharmacol Biopharm 16(10):456;1978
dihydrodigoxin  5297-10-9   Digoxin/*analogs & derivatives. Clin Chem 24(1):155;1978; Clin Chem 24(6):1086;1978; J Chromatogr 121(2):401;1976; J Chromatogr 125(3):523;1976
digoxin, etamivan, etofylline, hexobendine drug combination  0   *Benzamides *Digoxin *Hexobendine Drug Combinations Theophylline/*analogs & derivatives.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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