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Carbohydrate Epimerases

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Definition: Enzymes that catalyze the epimerization of chiral centers within carbohydrates or their derivatives. EC 5.1.3.     
Examples UDPglucose 4-Epimerase 		Other names Carbohydrate Isomerases; Isomerases, Carbohydrate; Epimerases, Carbohydrate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
heparan sulfate C5-epimerase, Drosophila  EC 5.1.3.-   *Carbohydrate Epimerases *Drosophila Proteins. Glycobiology 2011 May;21(5):607-18
UDP-N-acetylgalactosamine 4-epimerase, Pleisomonas shigelloides  EC 5.1.3.-   *Carbohydrate Epimerases. Protein Sci 2011 May;20(5):856-66
fucose mutarotase, mouse  EC 5.1.3.-   *Carbohydrate Epimerases. BMC Genet 2010;11:62
dermatan sulfate epimerase 1, mouse  EC 5.1.3.19   *Carbohydrate Epimerases. Mol Cell Biol 2009 Oct;29(20):5517-28
FucU protein, E coli  EC 5.1.3.-   *Carbohydrate Epimerases. J Mol Biol 2009 Aug 7;391(1):178-91
D-allulose 6-phosphate 3-epimerase, E coli  EC 5.1.3.1   *Carbohydrate Epimerases. Biochemistry 2008 Sep 9;47(36):9608-17
D-tagatose 3-epimerase, Pseudomonas cichorii  EC 5.1.3.-   *Carbohydrate Epimerases. J Mol Biol 2007 Nov 23;374(2):443-53
WlbD protein, Bordetella pertussis  EC 5.1.3.-   *Carbohydrate Epimerases. Biochem J 2007 Jul 1;405(1):123-30
WbpI protein, Pseudomonas aeruginosa  EC 5.1.3.-   *Carbohydrate Epimerases. Biochem J 2007 Jul 1;405(1):123-30
MUM4 protein, Arabidopsis  0   *Multienzyme Complexes *Arabidopsis Proteins Alcohol Oxidoreductases Carbohydrate Epimerases Hydro-Lyases. J Biol Chem 2007 Feb 23;282(8):5389-403
YMR099c protein, S cerevisiae  EC 5.1.3.15   *Carbohydrate Epimerases *Saccharomyces cerevisiae Proteins. J Biol Chem 2006 Oct 6;281(40):30175-85
rhamnose mutarotase, E coli  EC 5.1.3.-   *Carbohydrate Epimerases *Escherichia coli Proteins. J Mol Biol 2005 May 27;349(1):153-62
RENBP protein, human  EC 5.1.3.8   *Carbohydrate Epimerases *Carrier Proteins Renin.
Renbp protein, rat  EC 5.1.3.8   *Carbohydrate Epimerases *Carrier Proteins Renin.
Renbp protein, mouse  EC 5.1.3.8   *Carbohydrate Epimerases *Carrier Proteins Renin.
UDP-glucuronic acid 4-epimerase, Arabidopsis  EC 5.1.3.-   *Carbohydrate Epimerases *Arabidopsis Proteins. Plant Physiol 2004 Dec;136(4):4256-64
dTDP-rhamnose synthase, Arabidopsis  EC 5.1.3.13   *Carbohydrate Epimerases. Plant Physiol 2004 Apr;134(4):1337-46
dTDP-deoxyglucose epimerase, Streptomyces  EC 5.1.3.-   *Carbohydrate Epimerases. Biotechnol Lett 2004 Feb;26(3);185-91
fructoselysine 3-epimerase  EC 5.1.3.-   *Carbohydrate Epimerases. Biochem J 2004 Mar 15;378(Pt 3):1047-52
NovW Carbohydrate Epimerase  EC 5.1.3.-   *Carbohydrate Epimerases. Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1507-9
GDP-6-deoxy-D-talose synthetase, Actinobacillus actinomycetemcomitans  EC 5.1.3.-   *Carbohydrate Epimerases.
MUR4 protein, Arabidopsis  EC 5.1.3.-   *Carbohydrate Epimerases *Arabidopsis Proteins. Plant Cell 2003 Feb;15(2):523-31
dTDP-4-keto-6-deoxyglucose-5-epimerase  EC 5.1.3.-   *Carbohydrate Epimerases. Acta Crystallogr D Biol Crystallogr 2002 Jul;58(Pt 7):1226-8
galactose mutarotase  EC 5.1.3.3   *Carbohydrate Epimerases. J Biol Chem 2002 Jun 7;277(23):20854-61
XylM protein, Lactococcus lactis  EC 5.1.3.-   *Bacterial Proteins *Carbohydrate Epimerases. Appl Environ Microbiol 2001 Apr;67(4):1445-52
heparin-heparan sulfate-glucuronic acid C5-epimerase  EC 5.1.3.-   *Carbohydrate Epimerases. J Biol Chem 2001 Jun 15;276(24):21538-43
GER1 protein, Arabidopsis  EC 5.1.3.-   *Carbohydrate Epimerases *Arabidopsis Proteins. Plant J 2000 Mar;21(5):445-54
N-acylglucosamine-6-phosphate 2-epimerase  EC 5.1.3.9   *Carbohydrate Epimerases. Biochim Biophys Acta 1999 Aug 5;1428(2-3):305-13
N-acetylmannosamine-6-phosphate epimerase  EC 5.1.3.-   *Bacterial Proteins *Carbohydrate Epimerases. J Bacteriol 1999 Aug;181(15);4526-32
fcl protein, E coli  0   *Carbohydrate Epimerases *Ketone Oxidoreductases *Multienzyme Complexes *Escherichia coli Proteins. J Bacteriol 1998 Feb;180(4):998-1001
UDP acetylglucosamine-2-epimerase  EC 5.1.3.14   Carbohydrate Epimerases Escherichia coli Proteins. Tohoku J Exp Med 1980;131(3):209
maltose 1-epimerase  EC 5.1.3.-   *Carbohydrate Epimerases. FEBS Lett 1995 Jun 26;367(2):177-9
TDP-deoxyglucose epimerase  EC 5.1.3.-   *Carbohydrate Epimerases ATP-Binding Cassette Transporters. Mol Microbiol 1994 Mar;11(5):885-96
mannuronan c-5-epimerase  EC 5.1.3.-   *Carbohydrate Epimerases. J Bacteriol 1994 Apr;176(7):1821-30
thymidine-diphospho-4-keto-6-deoxyglucose epimerase  EC 5.1.3.-   *Carbohydrate Epimerases. Arch Biochem Biophys 1994 Jan;308(1):175-81
rffE protein, E coli  EC 5.1.3.14   *Carbohydrate Epimerases *Escherichia coli Proteins. J Bacteriol 1993 Nov;175(21):7074-80
perosamine synthetase  EC 5.1.3.-   *Transaminases *Carbohydrate Epimerases Bacterial Proteins Escherichia coli Proteins. J Bacteriol 1989;171(10):5694
paratose synthase  EC 5.1.3.-   *Carbohydrate Epimerases. J Bacteriol 1989;171(10):5694
abequose synthase  EC 5.1.3.-   *Carbohydrate Epimerases. J Bacteriol 1989;171(10):5687
chondroitin D-glucuronosyl 5-epimerase  EC 5.1.3.-   *Carbohydrate Epimerases. Anal Biochem 1983;131(1):146
ADP-L-glycero-D-mannoheptose-6-epimerase  EC 5.1.3.-   *Carbohydrate Epimerases. J Biol Chem 1983;258(3):1985
TSTA3 protein, human  EC 1.1.1.271   *Carbohydrate Epimerases *Ketone Oxidoreductases Blood Proteins. Blood 1981;57(2):209
N-acyl-D-glucosamine 2-epimerase  EC 5.1.3.8   *Carbohydrate Epimerases *Carrier Proteins. Clin Sci 1979;57(suppl 5):109s
UDPglucuronate 4-epimerase  EC 5.1.3.6 UDPgalacturonate 4-epimerase  *Carbohydrate Epimerases. Biochem J 162(2):211;1977; J Biol Chem 49(8):2366;1974
UDP-L-arabinose 4-epimerase  EC 5.1.3.5   *Carbohydrate Epimerases. Biochem J 162(2):267;1977; Biochem J 162(2):281;1977
UDP-N-acetylglucosamine 4-epimerase  EC 5.1.3.14   *Carbohydrate Epimerases. Biochem Med 19(2):202;1978; J Chromatogr 1979;169:495
L-ribulosephosphate 4-epimerase  EC 5.1.3.4   *Carbohydrate Epimerases Saccharomyces cerevisiae Proteins Escherichia coli Proteins. J Biol Chem 245(16):3988;1970
ribulosephosphate 3-epimerase  EC 5.1.3.1   *Carbohydrate Epimerases. Biochim Biophys Acta 570(2):352;1979
polymannuronic acid 5-epimerase  EC 5.1.3.-   *Carbohydrate Epimerases. Acta Chem Scand 27(9):3592;1973
dTDP-4-ketorhamnose 3,5-epimerase  EC 5.1.3.13   *Carbohydrate Epimerases Escherichia coli Proteins. Biochem Biophys Res Commun 64(3):1041;1975; Biochim Biophys Res Commun 568(1):243;1979
aldose 1-epimerase  EC 5.1.3.3   *Carbohydrate Epimerases. Anal Biochem 70:489;1976; Biochem Biophys Res Commun 88(3):968;1979; Carbohydr Res 58:267;1977; Chem Pharm Bull 22(10):2337;1974; Clin Chem 25(2):215;1979; Experientia 34(5):563;1978; J Biol Chem 248(12):4163;1973
heparosan N-sulfate D-glucuronosyl 5-epimerase  EC 5.1.3.17   *Carbohydrate Epimerases. J Biol Chem 254(8):2975;1979
GDPmannose 3,5-epimerase  EC 5.1.3.18   *Carbohydrate Epimerases. J Biol Chem 254(16):7600;1979
N-acetylmannosamine 2-epimerase  EC 5.1.3.-   *Carbohydrate Epimerases. Biochim Biophys Acta 585(4):535;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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