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Captopril

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Definition: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.     
Pharmacological Action Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents 		Other names SQ14534; SQ14225; SQ14,534; SQ14,225; SQ 14534; SQ 14225; SQ 14,534; SQ 14,225; SQ-14534; SQ-14225; SQ-14,534; SQ-14,225; Lopirin; Capoten; (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-prolineDrugs* : CAPOTEN; CAPTOPRIL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
captopril ethyl ester  0   Captopril/*analogs & derivatives. Drug Dev Ind Pharm 2010 Aug;36(8):926-32
silacaptopril  0   *Organosilicon Compounds Captopril/*analogs & derivatives Ligands. J Pept Sci 2010 Feb;16(2):91-7
4-fluorocaptopril  72180-18-8   Captopril/*analogs & derivatives. J Nucl Med 1991;32(9):1730
SQ 26703  81872-09-5   Captopril/*analogs & derivatives. J Pharmacol Exp Ther 1991;257(3):919
zofenoprilate  75176-37-3   Captopril/*analogs & derivatives. Horm Metab Res Suppl 1990;22:85
S-nitrosocaptopril  122130-63-6 L-Proline, 1-(2-methyl-3-(nitrosothio)-1-oxopropyl)-, (S)  Captopril/*analogs & derivatives. J Pharmacol Exp Ther 1989;249(3):726
captopril N-ethylmaleimide sulfone  109350-28-9   Captopril/*analogs & derivatives. J Chromatogr 1987;417(1):79
captopril N-ethylmaleimide sulfoxide  109350-29-0   Captopril/*analogs & derivatives. J Chromatogr 1987;417(1):79
S-benzylcaptopril  81276-20-2   Captopril/*analogs & derivatives. J Chromatogr 1987;417(1):79
desacetyl-alacepril  74259-08-8 L-Phenylalanine, N-(1-(3-mercapto-2-methyl-1-oxopropyl)-L-prolyl)-, (S)  Captopril/*analogs & derivatives. Arzneimittelforschung 1986;36(1):40
alacepril  74258-86-9   Captopril/*analogs & derivatives.
Pharma Action Angiotensin-Converting Enzyme Inhibitors 		Clin Pharmacol Ther 1985;38(4):462
S-benzoyl captopril  75714-71-5   Captopril/*analogs & derivatives. J Chromatogr 1985;342(1):186
captopril, hydrochlorothiazide drug combination  0   *Captopril *Hydrochlorothiazide Drug Combinations.
Pharma Action Angiotensin-Converting Enzyme Inhibitors ; Sodium Chloride Symporter Inhibitors 		J Cardiovasc Pharmacol 1985;7 Suppl 1:S63CAPOZIDE 25/15; CAPTOPRIL AND HYDROCHLOROTHIAZIDE; CAPOZIDE 50/15; CAPOZIDE 25/25; CAPOZIDE 50/25
zofenopril  81872-10-8 L-Proline, 1-(3-(benzoylthio)-2-methyl-1-oxopropyl)-4-(phenylthio)-, (1(R*),2alpha,4alpha)  Captopril/*analogs & derivatives.
Pharma Action Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents 		J Cardiovasc Pharmacol 1985;7 Suppl 1:S30
captopril-cysteine  75479-46-8   Captopril/*analogs & derivatives. Xenobiotica 1983;13(12):701
S-methylcaptopril  78636-29-0   Captopril/*analogs & derivatives. Biochem Pharmacol 1983;32(10):1563
captopril disulfide  64806-05-9   Captopril/*analogs & derivatives. Jpn J Pharmacol 1982;32(5):934

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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