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Bufanolides

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Definition: Cyclopentanophenanthrenes with a 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. They are found in BUFONIDAE and often possess cardiotonic properties.  includes bufenolides, bufatrienolides   
Pharmacological Action Cardiotonic Agents
Examples Proscillaridin 		Other names Bufadienolides
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
9-oxocinobufotalin 3-adipoylarginine ester  0   *Bufanolides Arginine/*analogs & derivatives. J Asian Nat Prod Res. 2011 Feb;13(2):111-6
bufogargarizin B  0   *Bufanolides. Chemistry. 2010 Sep 24;16(36):10989-93
bufogargarizin A  0   *Bufanolides. Chemistry. 2010 Sep 24;16(36):10989-93
tigencaoside B  0   *Bufanolides. Fitoterapia. 2010 Sep;81(6):636-9
tigencaoside A  0   *Bufanolides. Fitoterapia. 2010 Sep;81(6):636-9
bufotalin 3-pimeloylarginine ester  0   *Bufanolides. J Asian Nat Prod Res. 2010 Sep;12(9):793-800
cinobufotalin 3-nonanedioylarginine ester  0   *Bufanolides. J Asian Nat Prod Res. 2010 Sep;12(9):793-800
3-acetyl 15beta-hydroxyl bufotalin  0   *Bufanolides. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6062-5
riparianin  0   *Bufanolides. Phytochemistry 2007 Oct;68(19):2415-9
rubellin  0   *Bufanolides. S Afr Med J 1950 Oct 28;24(43):912-3
6beta-hydroxy-5beta-bufa-20,22-dienolide-3beta-O-beta-D-galactoside  0   *Bufanolides *Galactosides. Phytochemistry 2007 Jul;68(13):1731-4
3beta,16beta-dihydroxy-5beta-bufa-20,22-dienolide  0   *Bufanolides. Phytochemistry 2007 Jul;68(13):1731-4
12-oxohellebrigenin-3-O-4,6-dideoxyhexopyranoside  0   *Bufanolides *Saponins. Org Lett 2006 Nov 9;8(23):5207-10
hellebrigenin-3-O-fucopyranoside  0   *Bufanolides *Saponins. Org Lett 2006 Nov 9;8(23):5207-10
hellebrigenin-3-O-6'-deoxyglucopyranoside  0   *Bufanolides *Saponins. Org Lett 2006 Nov 9;8(23):5207-10
4beta,8beta,11alpha,14beta-tetrahydroxybufa-5,20,22-trienolide-12-one, 2alpha,3beta-O-4,6-dideoxy-L-glucose  0   *Bufanolides. Phytochemistry. 2006 Oct;67(19):2140-5
scillicyanosidin  0   *Bufanolides. Phytochemistry. 2006 Oct;67(19):2140-5
6beta-acetoxy-3beta,8beta,14beta-trihydroxy-12-oxobufa-4,20,22-trienolide  0   *Bufanolides. Phytochemistry. 2004 Dec;65(23):3069-73
14beta-hydroxybufa-3,5,20,22-tetraenolide  0   *Bufanolides. Phytochemistry. 2004 Dec;65(23):3069-73
20,21-epoxyresibufogenin-3-acetate  0   *Bufanolides. Biochem Biophys Res Commun 2004 Oct 22;323(3):1096-102
tyledoside D  0   *Bufanolides. Onderstepoort J Vet Res 2002 Sep;69(3):243-6
20,21-epoxyresibufogenin-3-formate  0   *Bufanolides Receptors, Interleukin-6/antagonists & inhibitors. J Pharmacol Exp Ther 2002 Oct;303(1):104-9
methyl daigremonate  0   *Bufanolides. Phytochemistry 2001 Sep;58(2):311-4
urginin  0   *Bufanolides. Phytochemistry 2001 Oct;58(4):557-61
12beta-hydroxyscillirosidin  0   *Bufanolides. Phytochemistry 2001 Oct;58(4):557-61
bryophyllin C  0   *Bufanolides. Biosci Biotechnol Biochem 2000 Jun;64(6):1310-2
marinosin  0   *Bufanolides Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1997 Feb;45(2):249-54
marinoic acid  0   *Bufanolides. Chem Pharm Bull (Tokyo) 1996 Jan;44(1):255-7
chan su  0   *Bufanolides Amphibian Venoms. Biol Neonate 1995;67(5):376-80
marinobufagenin  470-42-8   *Bufanolides.
Pharma Action Enzyme Inhibitors ; Vasoconstrictor Agents 		Eur J Pharamacol 1995 Feb 14;274(1-3):151-8
bufadienolide  29565-35-3   *Bufanolides. Chung Kuo Chung Yao Tsa Chih 1994 Jan;19(1):25-7
bufotalin 3-succinoylarginine ester  0   *Bufanolides Materia Medica. Yao Hsueh Hsueh Pao 1992;27(9):679-83
22,23-dihydrobufalin  123623-38-1 Buf-20-enolide, 3,14-dihydroxy-, (3beta,5beta)  *Bufanolides Cardiac Glycosides. Naunyn Schmiedebergs Arch Pharmacol 1990;342(5):598
cinobufotalin  1108-68-5   *Bufanolides Materia Medica. Clin Sci 1990;78(2):169
bryotoxin B  105608-31-9   *Bufanolides Cardiac Glycosides. Aust Vet J 1989;66(11):374
bryotoxin A  101329-50-4   *Bufanolides Cardiac Glycosides. Aust Vet J 1989;66(11):374
bryophyllin B  125339-13-1 Bufa-20,22-dienolide, 1-(acetyloxy)-11,19-epoxy-3,5,14,19-tetrahydroxy-, (1beta,3beta,5beta,11alpha,19R)  *Bufanolides Cytotoxins. J Nat Prod 1989;52(5):1071
bryophyllin A  105608-32-0   *Bufanolides Cardiac Glycosides. Chem Pharm Bull (Tokyo) 1988;36(4):1615
arenobufagin  464-74-4   *Bufanolides. Steroids 1986;48(3-4):251
physodine A  122188-47-0   *Bufanolides. Onderstepoort J Vet Res 1987 Dec;54(4):641
scillarenin  465-22-5   *Bufanolides. Arch Pharm (Weinheim) 1985;318(10):882
daigremontianin  98205-50-6 Bufa-20,22-dienolide, 1,3,5-(ethylidynetris(oxy))-11,14-dihydroxy-12,19-dioxo-, (1beta(R),3beta,5beta,11alpha)  *Bufanolides Crassulaceae. Planta Med 1985;(2):169
acrihellin  67696-82-6 Bufa-20,22-dienolide, 5,14-dihydroxy-3-((3-methyl-1-oxo-2-butenyl)oxy)-19-oxo-, (3beta,5beta)  *Bufanolides Cardiac Glycosides. Arzneimittelforsch 1983;33(8):1106
cotyledoside  57364-74-6   *Bufanolides Cardiac Glycosides. Onderstepoort J Vet Res 1982;49(4):247
bufotoxin  464-81-3   *Bufanolides Toxins, Biological. Chem Pharm Bull (Tokyo) 1980;28(5):1559
scilliroside  507-60-8 6 beta-(acetyloxy)-3-beta-(beta-D-glucopyranosyloxy)-8,14-dihydroxybufa-4,20,22-trienolide  *Bufanolides Cardiac Glycosides. Lloydia 42(5):522;1979
scillaren A  124-99-2 3 beta-((6-deoxy-4-O-beta-D-glucopyranosyl- alpha-L-mannopyranosyl)oxy)-14-hydroxy-bufa-4, 20,22-trienolide  *Bufanolides Cardiac Glycosides. Lloydia 42(5):522;1979
bufalin  465-21-4 3,14-dihydroxy-bufa-20,22-dienolide  *Bufanolides Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors Materia Medica.
Pharma Action Antineoplastic Agents ; Cardiotonic Agents ; Enzyme Inhibitors 		Chem Pharm Bull (Tokyo) 25(1):64;1977; Jap J Pharmacol 24(1):97;1974
telocinobufagin  472-26-4 3,5,14-trihydroxybufa-20,22-dienolide  *Bufanolides. J Org Chem 39(17):2632;1974
scillicyanoside  11005-49-5   *Bufanolides Cardiac Glycosides. Helv Chim Acta 56(7):2117;1973
poaefusarin  39284-87-2   *Bufanolides Mycotoxins. Appl Microbiol 26(5):719;1973
14-hydroxy-3-oxo-1,4,20,22-bufatetraenolide  41059-91-0   *Bufanolides. Planta Med 24(3):201;1973
hellebrin  13289-18-4   *Bufanolides Cardiac Glycosides Ranunculaceae. Acta Pharm Hung 47(4):162;1977; Planta Medica 26(3):250;1974
bufarenogin  17008-65-0   *Bufanolides. Helv Chim Acta 56(1):2827;1973
argentinogen  4236-48-0   *Bufanolides. Helv Chim Acta 56(1):2827;1973
bufogenin  465-39-4 14,15 beta-epoxy-3 beta-hydroxy-5 beta-bufa-20,22-dienolide  *Bufanolides.
bufotalin  471-95-4 3 beta-14,16 beta-trihydroxy-5 beta-bufa-20,22-dienolide  *Bufanolides.
cinobufagin  470-37-1   *Bufanolides Amphibian Venoms Materia Medica. Bull Acad Med Belg 129(5):363;1974; J Org Chem 37(25):4040;1972; Jpn Heart J 19(5):775;1978
hellebrigenin  465-90-7   *Bufanolides. Molec Pharmacol 8(1):31;1972

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