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Arachidonate 5-Lipoxygenase

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Definition: An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.      Other names 5-Lipoxygenase; Synthetase, Leukotriene A4; Synthase, Leukotriene A4; Synthase, Leukotriene A; Synthase, LTA4; Arachidonic Acid 5 Lipoxygenase; Arachidonate 5 Lipoxygenase; 5-Lipoxygenase, Arachidonic Acid; 5-Lipoxygenase, Arachidonate; 5 Lipoxygenase; Leukotriene A4 Synthetase; Leukotriene A4 Synthase; Leukotriene A Synthase; LTA4 Synthase; Arachidonic Acid 5-Lipoxygenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(4-aminophenyl)-3-(3,5-dihydroxylphenyl)propenoic acid  0   *Aniline Compounds *Caffeic Acids Arachidonate 5-Lipoxygenase/antagonists & inhibitors Cyclooxygenase 1 Cyclooxygenase 2. Basic Clin Pharmacol Toxicol 2009 Nov;105(5):350-6
2-(4-hydroxyphenyl)-3-(3,5-dihydroxyphenyl)propenoic acid  0   *Phenylpropionates Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Eur J Pharmacol 2009 Jun 2;611(1-3):100-6
12-labdene-15,16,(8)17-trial  0   *Diterpenes Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Biosci Biotechnol Biochem 2006 Oct;70(10):2494-500
5-Loxin  0   *Plant Extracts *Triterpenes Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Arthritis Res Ther 2008;10(4):R85
S 30621  0   *Hydroxamic Acids *Phenylurea Compounds Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Carcinogenesis 2007 May;28(5):957-61
S 29606  0   *Hydroxamic Acids *Phenylurea Compounds Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Carcinogenesis 2007 May;28(5):957-61
4-(5-fluoro-3-(4-(2-methyl-1H-imidazol-1-yl)benzyloxy)phenyl)-4-methoxy-3,4,5,6-tetrahydro-2H-pyran  0   *Imidazoles *Pyrans Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Bioorg Med Chem 2003 Sep 1;11(18):3879-87
4-(5-fluoro-3-(4-(2-methyl-1H-imidazol-1-yl)benzyloxy)phenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide  0   *Imidazoles *Pyrans Arachidonate 5-Lipoxygenase/antagonists & inhibitors. J Med Chem 2004 Jan 29;47(3):720-5
N-4-(4-fluorophenylaminosulfonyl)benzoisoselenothiazolidone  0   *Sulfonamides *Organoselenium Compounds Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Yao Xue Xue Bao 2001 Oct;36(10):735-8
N-4-(4-methoxyphenylaminosulfonyl)benzoisoselenothiazolidone  0   *Sulfonamides *Organoselenium Compounds Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Yao Xue Xue Bao 2001 Oct;36(10):735-8
1,6-dimethyl-2-(4'-N-n-propylsuccinamido)methyl-3-hydroxypyridin-4(1H)-one  0   *Pyridones Arachidonate 5-Lipoxygenase/antagonists & inhibitors. J Med Chem 2002 Jan 31;45(3):631-9
3-oxo-tirucall-8,24-dien-21-oic acid  0   *Triterpenes Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Mol Pharmacol 2001 Aug;60(2):267-73
ocobullenone  149990-50-1   *Dioxanes Arachidonate 5-Lipoxygenase/antagonists & inhibitors Stereoisomerism. Phytochemistry 2000 Jul;54(6):591-5
S 2474  0   *Cyclic S-Oxides *Thiazoles Arachidonate 5-Lipoxygenase/antagonists & inhibitors. J Med Chem 2000 May 18;43(10):2040-8
CMI 392  0   Urea/*analogs & derivatives *Furans Arachidonate 5-Lipoxygenase/antagonists & inhibitors. J Med Chem 1998 May 21;41(11):1970-9
L 708780  0   *Naphthalenes *Nitriles Arachidonate 5-Lipoxygenase/antagonists & inhibitors. J Med Chem 1996 Sep 27;39(20):3951-70
1-phenylperhydro-1,2,4-triazin-3-one  0   *Triazines Arachidonate 5-Lipoxygenase/antagonists & inhibitors. J Med Chem 1996 Sep 27;39(20):3938-50
N-hydroxy-N-(1-(2-phenylbenzofuran-5-yl)ethyl)urea  0   *Benzofurans Arachidonate 5-Lipoxygenase/antagonists & inhibitors. J Med Chem 1994 Oct 14;37(21):3663-7
5-(N-hydroxy-N-(1-(2-(3,4,5-trimethoxyphenyl)-5-benzofuranyl)ethyl)amino)-5-oxopentanoate  0   *Benzofurans Arachidonate 5-Lipoxygenase/antagonists & inhibitors. J Med Chem 1994 Oct 14;37(21):3663-7
N-hydroxy-N-(1-(2-phenyl-5-benzofuranyl)ethyl)furancarboxamide  0   *Benzofurans Arachidonate 5-Lipoxygenase/antagonists & inhibitors. J Med Chem 1994 Oct 14;37(21):3663-7
2',5'-dimethoxy-3,4-dihydroxychalcone  152809-88-6   *Chalcones Arachidonate 5-Lipoxygenase/antagonists & inhibitors. J Med Chem 1993 Nov 26;36(24):3904-9
camelliaside C  152390-63-1   *Glycosides *Kaempferols Arachidonate 5-Lipoxygenase/antagonists & inhibitors Camellia. Chem Pharm Bull (Tokyo) 1993 Jun;41(6):1185-7
chebulagic acid  23094-71-5   *Benzopyrans *Glucosides Arachidonate 5-Lipoxygenase/antagonists & inhibitors DNA Topoisomerases, Type I/antagonists & inhibitors. J Nat Prod 1992 Apr;55(4):401-13
N-linoleoyldopamine  105955-12-2 9,12-Octadecadienamide, N-(2-(3,4-dihydroxyphenyl)ethyl)-, (Z,Z)  Dopamine/*analogs & derivatives Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1992 Feb;40(2):396-400
L 670630  133174-26-2   *Benzofurans Arachidonate 5-Lipoxygenase/antagonists & inhibitors. J Med Chem 1992 Apr 3;35(7):1299-318
SC 45662  137803-61-3   *Acetic Acids *Phenols Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Transplant Proc 1991;23(1 Pt 2):1074
3-(5-hydroxy-4,6,7-trimethyl-1,3-benzoxathiazol-2-yl)propanol  100480-81-7   *Benzoxazoles Arachidonate 5-Lipoxygenase/antagonists & inhibitors Asthma/drug therapy. J Med Chem 1990;33(5):1491
oxphaman  112851-89-5 1,4-Benzenediol, 2-((tricyclo(3.3.1.13,7)dec-1-ylimino)methyl)  Adamantane/*analogs & derivatives Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Pharmazie 1989;44(8):550
LY 178002  107889-32-7 4-Thiazolidinone, 5-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)  *Thiazolidines Arachidonate 5-Lipoxygenase/antagonists & inhibitors Phospholipases A/antagonists & inhibitors. Agents Actions 1989;27(3-4):300
5-hexyloxy-3',4'-dihydroxy-6,7-dimethoxyflavone 4'-phosphate  111372-46-4 4H-1-Benzopyran-4-one, 5-(hexyloxy)-2-(3-hydroxy-4-(phosphonooxy)phenyl)-6,7-dimethoxy  *Flavonoids Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Stroke 1989;20(2):248
Wy 45911  105785-61-3   *Quinolines Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Adv Prostaglandin Thromboxane Leukotriene Res 1987;17A:536

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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