CD4-Positive T-Lymphocytes (definition)

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CD4-Positive T-Lymphocytes

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Definition: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.

subpopulations: index specifics if available or coordinate CD4-POSITIVE T-LYMPHOCYTES with T-LYMPHOCYTE SUBSETS; count: coordinate IM with CD4 LYMPHOCYTE COUNT (NIM)
See Also Acquired Immunodeficiency Syndrome; Antigens, CD4; CD4-CD8 Ratio; T-Lymphocytopenia, Idiopathic CD4-Positive
Examples T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory

Other names T4 Cells; T4 Lymphocytes; T4 Lymphocyte; T-Lymphocytes, CD4-Positive; T-Lymphocyte, CD4-Positive; Lymphocytes, CD4-Positive; Lymphocyte, CD4-Positive; CD4-Positive T-Lymphocyte; CD4-Positive Lymphocyte; CD4 Positive T Lymphocytes; CD4-Positive Lymphocytes; T4 Cell

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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