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Necrosis

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Definition: The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. Distinguish it from APOPTOSIS which is a normal, regulated cellular process.  IM for general or for necrotic process; necrosis in an organ or tissue: index organ or tissue /pathol (IM) + NECROSIS (NIM); note specific necrosis terms; radionecrosis: index RADIATION INJURIES/pathol (IM) + organ /pathol (IM) + NECROSIS (NIM)   
See Also Apoptosis; Tumor Necrosis Factor-alpha
Examples Dental Pulp Necrosis; DNA Degradation, Necrotic; Fat Necrosis; Gangrene; Infarction; Osteonecrosis 		Other names Necroses

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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