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12-HPETE

under Leukotrienes
More information in Books or onNLM PubMed
More on Leukotrienes Definition: A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.  eicosanoids; GEN or unspecified; prefer specifics; /biosyn /physiol permitted   
SubstanceCAS Registry & nameCategoriesSourceDrugs*
12-HPETE [ 12-HPETE, (E,Z,Z,Z)-isomer,12-HPETE, (S-(E,E,E))-isomer,12-HPETE, (S-(E,Z,Z,Z))-isomer,12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid,12-OOHETE,12-hydroperoxy-5,8,10,14-icosatetraenoic acid,arachidonic acid omega-9 hydroperoxide,omega-9 HPAA,omega-9-hydroperoxyarachidonic acid ]
  RN given refers to cpd without isomeric designation; 12-HPETE may be used inconsistently in literature as synonym for cpds with various tetraene-locants; caused dose-dependent constriction of cat coro 		67675-13-2 (S-(E,E,E))-12-hydroperoxy-5,8,10,14-eicosatetraenoic acid  *Leukotrienes
Pharma Action Platelet Aggregation Inhibitors; Vasoconstrictor Agents 		Biochem Biophys Res Commun 89(4):1273;1979; Proc Natl Acad Sci USA 1980;77(1):308; Prostaglandins 1979;18(6):909

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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